Document Detail

The effect of angiostatin on vascular leakage and VEGF expression in rat retina.
MedLine Citation:
PMID:  15094037     Owner:  NLM     Status:  MEDLINE    
Angiostatin is a potent angiogenic inhibitor. The present study identified a new activity of angiostatin: reducing vascular leakage, which is associated with diabetic macular edema, tumor growth and inflammation. An intravitreal injection of angiostatin significantly reduced retinal vascular permeability in rats with oxygen-induced retinopathy and in those with streptozotocin-induced diabetes, but not in normal rats. Consistent with its effect on permeability, angiostatin downregulated vascular endothelial growth factor (VEGF) expression in the retina in both the rat models but not in normal controls. These results suggest that the effect of angiostatin on vascular leakage is mediated, at least in part, through blockade of VEGF overexpression.
Jing Sima; Sarah X Zhang; Chunkui Shao; James Fant; Jian-xing Ma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  564     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-06-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Department of Medicine, The University of Oklahoma Health Sciences Center, 941 Stanton L. Young Blvd., BSEB 328B, Oklahoma City, OK 73104, USA.
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MeSH Terms
Angiogenesis Inhibitors / pharmacology
Angiostatins / pharmacology*
Capillary Permeability / drug effects*
Diabetes Mellitus, Experimental
Diabetic Retinopathy / etiology
Retina / metabolism
Retinal Vessels / drug effects*
Vascular Endothelial Growth Factor A / biosynthesis*
Grant Support
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Vascular Endothelial Growth Factor A; 86090-08-6/Angiostatins

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