| The effect of anesthesia and surgery on diaphragmatic lymph vessel flow after endotoxin in sheep. | |
| | |
MedLine Citation:
|
PMID: 2250484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Increases in diaphragmatic lymph vessel flow (Qdi) may be important in preventing ascites because diaphragmatic lymph vessels drain the peritoneal space. However, lymphatic vessel function may be depressed in anesthetized, open chested animals. To test this hypothesis, we cannulated diaphragmatic lymph vessels in five sheep which were anesthetized with 1-2% halothane. We performed a thoracotomy and cannulated a diaphragmatic lymph vessel in each sheep. Then we infused 0.75-1.0 micrograms/kg of E. coli endotoxin intravenously and we measured Qdi and the lymph protein concentration for 2-4 hrs. The data were compared to previously reported data for five unanesthetized sheep (J. Appl. Physiol. 62:706-710, 1987). At baseline Qdi = 0.8 +/- 0.7 (SD) in the anesthetized sheep and 1.0 +/- 0.8 ml/hr in the unanesthetized sheep. After endotoxin, Qdi increased to 4.5 +/- 3.1 ml/hr in the unanesthetized sheep (p less than 0.05) but Qdi did not change in the anesthetized sheep. However, the lymph protein concentration increased similarly in each group, indicating that endotoxin caused the same degree of injury in each group. Our results indicate that diaphragmatic lymph vessel function is depressed in anesthetized, open chested sheep. |
| | |
Authors:
|
J R Elk; T Adair; R E Drake; J C Gabel |
Related Documents
:
|
10795554 - Frequency of pancreatitis after endoscopic retrograde cholangiopancreatography with iop... 1503494 - Isolation of human skin-derived lymph: flow and output of cells following sodium lauryl... 1121644 - On the fate of dna synthesizing lymphoid blood cells in hodgkin's disease. 11414314 - Differential effects of et-1, et-2, and et-3 on pancreatic microcirculation, tissue int... 2046704 - The cytokinesis-block micronucleus assay as a biological dosimeter in spleen and periph... 19921364 - Complexity of blood volume control system and its implications in perioperative fluid m... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Lymphology Volume: 23 ISSN: 0024-7766 ISO Abbreviation: Lymphology Publication Date: 1990 Sep |
Date Detail:
|
Created Date: 1991-01-16 Completed Date: 1991-01-16 Revised Date: 2006-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 0155112 Medline TA: Lymphology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 145-8 Citation Subset: IM |
Affiliation:
|
Center for Microvascular and Lymphatic Studies, University of Texas Medical School, Houston. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Anesthesia* Animals Ascites / physiopathology, prevention & control Blood Pressure Diaphragm Endotoxins / pharmacology* Escherichia coli* Infusions, Intravenous Lymphatic System / physiopathology*, surgery Pulmonary Artery / physiology Sheep |
| Chemical | |
Reg. No./Substance:
|
0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diameters of lymphatic capillaries in patients with different forms of primary lymphedema.
Next Document: Effect of interleukin-2 on microvascular liquid and protein transport in the rat small intestine.