Document Detail

The effect of androgens on lipids.
MedLine Citation:
PMID:  23422242     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids.
RECENT FINDINGS: Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials.
SUMMARY: There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone administration in hypogonadal men. The overall effect of testosterone on CVD risk has not been definitively determined.
Anne K Monroe; Adrian S Dobs
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in endocrinology, diabetes, and obesity     Volume:  20     ISSN:  1752-2978     ISO Abbreviation:  Curr Opin Endocrinol Diabetes Obes     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-09-26     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  101308636     Medline TA:  Curr Opin Endocrinol Diabetes Obes     Country:  England    
Other Details:
Languages:  eng     Pagination:  132-9     Citation Subset:  IM    
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MeSH Terms
Androgens / blood,  metabolism*,  therapeutic use
Cardiovascular Diseases / blood*,  drug therapy,  metabolism,  physiopathology
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cross-Sectional Studies
Follicle Stimulating Hormone / blood
Hypogonadism / blood,  drug therapy*,  metabolism
Lipids / blood*
Prospective Studies
Randomized Controlled Trials as Topic
Risk Factors
Testosterone / blood,  metabolism*,  therapeutic use
Reg. No./Substance:
0/Androgens; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 3XMK78S47O/Testosterone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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