| The effect of anaesthetic agents on platelet function. | |
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MedLine Citation:
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PMID: 1822977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews studies which have investigated the effect of anaesthetic agents on platelet function. The results of these studies suggest that halothane is the only agent in current use which inhibits platelet function in concentrations used clinically. Nitrous oxide appears to cause only a modest inhibition, while enflurane and isoflurane appear to have minimal or negligible effects. There is no current evidence that intravenous induction agents, opiates, or muscle relaxants affect platelet function. Reports indicate that local anaesthetic agents inhibit platelet aggregation, but only at concentrations far greater than peak plasma concentrations found during clinical use. Epidural anaesthesia may be associated with a reduction in platelet aggregation through a mechanism unrelated to direct local anaesthetic inhibition. The clinical significance of the effect of halothane on platelet function is not known. However, it is possible that halothane may affect bleeding or thrombotic complications in a similar manner to other 'anti-platelet' drugs. |
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Authors:
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N M Gibbs |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 19 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-01-23 Completed Date: 1992-01-23 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 495-505 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Sir Charles Gairdner Hospital, Perth, Western Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics
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pharmacology* Anesthetics, Local / pharmacology Animals Blood Platelets / drug effects*, physiology Humans Platelet Activation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Anesthetics, Local |
| Comments/Corrections | |
Comment In:
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Anaesth Intensive Care. 1992 May;20(2):252-4
[PMID:
1497747
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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