Document Detail


The effect of anabolic steroids on anemia in myelofibrosis with myeloid metaplasia: retrospective analysis of 39 patients in Japan.
MedLine Citation:
PMID:  17483079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between 1999 and 2005, 285 patients received new diagnoses of myelofibrosis with myeloid metaplasia (MMM) in Japan. Anemic symptoms were present in 162 patients, and hemoglobin (Hb) concentrations were <10 g/dL in 197 patients. Fifty-five MMM patients were treated with anabolic steroids, and their effect on anemia during MMM was evaluated in 39 patients. A "good" response was defined as an Hb increase of >or=1.5 g/dL, cessation of transfusion dependence, and an Hb concentration of >10 g/dL maintained for at least 8 weeks. A "minimum" response was defined as an Hb increase of >or=1.5 g/dL and transfusion independence for at least 8 weeks. Both good and minimum responses were considered "favorable." Favorable responses were achieved in 17 patients (44%, 8 good and 9 minimum responses). None of the pretreatment variables, such as the lack of transfusion dependence, a higher Hb concentration at the start of treatment, or the absence of cytogenetic abnormalities, were associated with a response to anabolic steroid therapy. Adverse events associated with anabolic steroid therapy were moderate and transient. Two patients required definitive withdrawal of treatment. Thus, anabolic steroids are well tolerated and effective for the treatment of anemia in a subset of MMM patients.
Authors:
Kazuya Shimoda; Kotaro Shide; Kenjirou Kamezaki; Takashi Okamura; Naoki Harada; Naoko Kinukawa; Kazuma Ohyashiki; Yoshiyuki Niho; Hideaki Mizoguchi; Mitsuhiro Omine; Keiya Ozawa; Mine Haradaa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of hematology     Volume:  85     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-08-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
Affiliation:
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. kshimoda@med.miyazaki-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anabolic Agents / administration & dosage*,  adverse effects
Anemia / blood,  complications,  genetics,  therapy*
Blood Transfusion
Chromosome Aberrations
Danazol / administration & dosage*,  adverse effects
Estrogen Antagonists / administration & dosage*,  adverse effects
Female
Hemoglobins / analysis
Humans
Male
Methenolone / administration & dosage,  adverse effects,  analogs & derivatives*
Middle Aged
Primary Myelofibrosis / blood,  complications,  genetics,  therapy*
Time Factors
Chemical
Reg. No./Substance:
0/Anabolic Agents; 0/Estrogen Antagonists; 0/Hemoglobins; 153-00-4/Methenolone; 17230-88-5/Danazol; 434-05-9/methenolone acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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