Document Detail

The effect of ammonia on stalk cell formation in submerged monolayers of Dictyostelium discoideum.
MedLine Citation:
PMID:  6687049     Owner:  NLM     Status:  MEDLINE    
It has been shown that ammonia inhibits stalk cell formation in monolayers of V12M2, and it was suggested that this inhibition was due to an antagonism of the differentiation-inducing factor (DIF) (Gross, J.D. et al., Nature, 303, 244-246, 1983). However, the results presented here indicate that ammonia inhibition is independent of DIF concentration, and that it occurs well in advance of the period of DIF requirement. Ammonia completely inhibits DIF accumulation and inhibits stalk cell differentiation, but there is no inhibition of prespore cell formation. These results imply the existence of an early ammonia-sensitive event that influences terminal cell type differentiation.
N Neave; A Sobolewski; G Weeks
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell differentiation     Volume:  13     ISSN:  0045-6039     ISO Abbreviation:  Cell Differ.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-06-21     Completed Date:  1984-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342640     Medline TA:  Cell Differ     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM    
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MeSH Terms
Ammonia / pharmacology*
Cell Differentiation / drug effects
Glycoproteins / antagonists & inhibitors,  biosynthesis
Growth Inhibitors*
Leukemia Inhibitory Factor
Myxomycetes / cytology,  drug effects*,  enzymology,  growth & development
Time Factors
Reg. No./Substance:
0/Glycoproteins; 0/Growth Inhibitors; 0/Interleukin-6; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 7664-41-7/Ammonia

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