Document Detail

The effect of amitriptyline on inhibitory avoidance in mice is dose-dependent.
MedLine Citation:
PMID:  19861093     Owner:  NLM     Status:  MEDLINE    
The purpose of the present work was to study the dose-effect relationship of the antidepressant amitriptyline on inhibitory avoidance in male and female mice. Subjects received physiological saline or 2.5, 5, 10 or 20 mg/kg of amitriptyline hydrochloride 30 min before the training phase, and were subjected to the test phase 24 h later. Results showed a clear impairing effect of amitriptyline on inhibitory avoidance in both male and female mice, and that the effect is dose-dependent.
Andr?s Parra; Concepci?n Vinader-Caerols; Ar?nzazu Ferrer-A??; Adoraci?n Urquiza; Santiago Monle?n
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psicothema     Volume:  21     ISSN:  0214-9915     ISO Abbreviation:  Psicothema     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-28     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189384     Medline TA:  Psicothema     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  528-30     Citation Subset:  IM    
Facultad de Psicolog?a, Universidad de Valencia, Spain.
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MeSH Terms
Amitriptyline / administration & dosage,  pharmacology*
Avoidance Learning / drug effects*
Depression, Chemical
Dose-Response Relationship, Drug
Random Allocation
Reaction Time / drug effects
Reg. No./Substance:

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