Document Detail

The effect of amiodarone on cardiac rhythm after cardiopulmonary bypass in patients with atrial fibrillation.
MedLine Citation:
PMID:  21214105     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: The intraoperative use of amiodarone in patients with atrial fibrillation (AF) undergoing valvular heart surgery was unclear. Hence, a randomized clinical trial was designed to evaluate the effect of amiodarone on cardiac recovery and rhythm following mitral valve surgery.
METHODS: A total of 120 elective mitral valve replacement patients with AF received either amiodarone (5 mg/kg) or the same volume of saline during cardiopulmonary bypass (CPB), in a randomized manner. Cardiac recovery was assessed by the heart auto re-beat ratio, the time from reperfusion to heart beat, the post-reperfusion rhythm, pacemaker use, and vasoactive drug use.
RESULTS: A higher heart auto re-beat ratio, higher sinus rhythm ratio, lower electric defibrillation ratio and less dopamine usage were found in the amiodarone treatment group. However, the proportion of temporary pacemaker use was lower in the control group.
CONCLUSION: Amiodarone had a good effect on cardiac recovery and the rhythm of AF patients after CPB.
Sun Jie; Chen Yu; Lu Xiaohu; Qian Yanning; Ding Zhengnian; Tang Xiaoyang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  19     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  786-8     Citation Subset:  IM    
Department of Anesthesiology, Jiangsu Province Hospital, Nanjing Medical University, Nanjing 210029, PR China.
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MeSH Terms
Amiodarone / administration & dosage*
Anti-Arrhythmia Agents / administration & dosage*
Atrial Fibrillation / complications,  drug therapy*,  physiopathology
Cardiac Pacing, Artificial
Cardiopulmonary Bypass* / adverse effects
Dobutamine / therapeutic use
Electric Countershock
Heart Rate / drug effects*
Heart Valve Diseases / complications,  physiopathology,  surgery*
Heart Valve Prosthesis Implantation* / adverse effects
Intraoperative Care
Mitral Valve / physiopathology,  surgery*
Recovery of Function
Surgical Procedures, Elective
Time Factors
Treatment Outcome
Vasoconstrictor Agents / therapeutic use
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Vasoconstrictor Agents; 1951-25-3/Amiodarone; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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