Document Detail


The effect of alkaline pH and transmural pressure on arterial constriction and membrane potential of hypertensive cerebral arteries.
MedLine Citation:
PMID:  3106928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
These studies were undertaken to examine the effect of alkalosis to modify "pressure-induced" activation of isolated cerebral arteries from spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls. At pH 7.4 and PCO2 of 34 torr elevation of transmural pressure from 0-140 mm Hg resulted in myogenic activation preceded by membrane depolarization in both SHR and WKY. The degree of developed myogenic tone in SHR was elevated above WKY. Alkalosis (pH 7.4-7.7) depolarized and activated SHR cerebral arteries to a greater extent than WKY. Furthermore, both the electrical and mechanical responses to elevation in transmural pressure were exaggerated in SHR compared to WKY at pH 7.7 (PCO2 constant at 34 torr). Manipulation of PCO2 at constant pH of 7.4 had similar effects on "pressure-induced" myogenic tone in both SHR and WKY. Thus, cerebral arteries from both SHR and WKY depolarize and develop myogenic tone in response to increasing transmural pressure. This response is augmented in SHR, but to a much greater extent upon elevation of extracellular pH, while PCO2 is maintained within normal limits. The implications of these findings are discussed.
Authors:
J S Smeda; J H Lombard; J A Madden; D R Harder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  408     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-10     Completed Date:  1987-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  239-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Dioxide / pharmacology
Cerebral Arteries / physiopathology*
Hydrogen-Ion Concentration
Hypertension / physiopathology*
Membrane Potentials / drug effects
Pressure
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Vasoconstriction* / drug effects
Verapamil / pharmacology
Grant Support
ID/Acronym/Agency:
31871//PHS HHS; 33833//PHS HHS
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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