Document Detail

The effect of aldosterone on the accumulation of adenosine 3':5'-cyclic monophosphate in toad bladder epithelial cells in response to vasopressin and theophylline.
MedLine Citation:
PMID:  4337239     Owner:  NLM     Status:  MEDLINE    
Vasopressin and theophylline both increase the content of adenosine 3':5'-cyclic monophosphate (cAMP) in epithelial cells of the urinary bladder of toads (Bufo marinus). Incubation of the tissue with 0.2 muM aldosterone markedly increases this response to the two agents; incubation for a similar time without steroid reduces the response. The permeability responses (sodium transport and water flow) of the intact tissue to vasopressin, theophylline, and exogenous cAMP are also considerably greater in bladders incubated with aldosterone than without. The results are interpreted as indicating that the foregoing permissive effects of aldosterone on the permeability responses to vasopressin and theophylline are mediated by a steroid-dependent increase in the accumulation of cAMP in the pertinent epithelial cells, probably as a consequence of a diminution in the rate of degradation of the intracellular nucleotide.
J S Stoff; J S Handler; J Orloff
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  69     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1972 Apr 
Date Detail:
Created Date:  1972-07-20     Completed Date:  1972-07-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  805-8     Citation Subset:  IM    
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MeSH Terms
Aldosterone / pharmacology*
Biological Transport / drug effects
Bufo marinus
Cell Membrane Permeability / drug effects
Cyclic AMP / analysis,  metabolism*
Dexamethasone / pharmacology
Drug Interactions
Drug Synergism
Epithelial Cells
Epithelium / analysis,  drug effects,  metabolism
Sodium / metabolism
Stimulation, Chemical
Testosterone / pharmacology
Theophylline / pharmacology*
Time Factors
Urinary Bladder / cytology,  drug effects,  metabolism*
Vasopressins / pharmacology*
Reg. No./Substance:
11000-17-2/Vasopressins; 50-02-2/Dexamethasone; 52-39-1/Aldosterone; 58-22-0/Testosterone; 58-55-9/Theophylline; 60-92-4/Cyclic AMP; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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