Document Detail

The effect of aging on the transarterial wall oxygen gradient.
MedLine Citation:
PMID:  7786699     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis is associated with aging based on numerous epidemiologic studies, whereas arterial wall hypoxia has been associated with other risk factors for atherosclerosis. We studied the effect of age on the transarterial wall oxygen gradient in the rat using an oxygen microelectrode. A decrease in oxygen tension in the outer 35% of the artery wall was noted in 36- to 40-week-old rats when compared to 3- to 4-week-old rats. These findings were noted despite no difference in arterial blood oxygen tension between the two groups and prior to any histologic evidence of atherosclerotic lesion formation. Our observations suggest that aging decreases the delivery of oxygen to the outer artery wall.
S M Santilli; R B Stevens; J G Anderson; M D Caldwell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  9     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  146-51     Citation Subset:  IM    
Department of Surgery, University of Minnesota Hospital and Clinics, Minneapolis 55455, USA.
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MeSH Terms
Aging / metabolism*,  pathology
Analysis of Variance
Aorta, Abdominal / metabolism*,  pathology
Blood Pressure
Oxygen / blood,  metabolism*
Partial Pressure
Rats, Inbred F344
Reg. No./Substance:

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