Document Detail

The effect of aging on extra-adrenal catecholamine storing cells of the rat.
MedLine Citation:
PMID:  6493434     Owner:  NLM     Status:  MEDLINE    
Cell number and catecholamine histofluorescence were determined in three extra-adrenal chromaffin tissues: the abdominal paraganglia, the carotid body and SIF (small intensely fluorescent)-cells, of male Fischer-344 rats at different ages. Catecholamines were demonstrated using the formaldehyde-induced fluorescence method. The number of paraganglia cells in the retroperitoneal area increased 13.6 fold between 3 and 33 months of age, and the volume of abdominal paraganglia approached 65% of the volume of one adrenal medulla. The emission color of some paraganglia cells shifted from greenish-yellow to yellowish-brown with aging, but differences were not observed in cell number of fluorophore color in the carotid body, a chemoreceptor type of paraganglion. The number of SIF cells (an intraganglionic variant of extra-adrenal chromaffin tissue) in the hypogastric ganglion increased significantly between 3 and 33 months. The pronounced increase of the volume of the paraganglia in aged rats may contribute to elevated concentrations of circulating catecholamines in these animals.
M Partanen; I Linnoila; A Hervonent; S I Rapoport
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurobiology of aging     Volume:  5     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-30     Completed Date:  1984-11-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
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MeSH Terms
Catecholamines / metabolism*
Chromaffin System / metabolism*
Microscopy, Fluorescence
Paraganglia, Chromaffin / metabolism
Rats / physiology*
Rats, Inbred F344
Vagus Nerve / metabolism
Reg. No./Substance:

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