Document Detail


The effect of aging and acute illness on delayed hypersensitivity.
MedLine Citation:
PMID:  235584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A group of standard antigens (monilia, mosquito, mumps, purified protein derivative [PPD], staphylococcus toxoid, streptokinase-streptodornase [sk-sd] and trichophyton) were applied to 321 normal volunteers, 60 patients admitted to a medical ward, and 41 patients in an intensive care unit (ICU) to evaluate their delayed hypersensitivity skin test response. Eighty-eight per cent of the normal subjects reacted with at least 5 mm. induration to one or more skin tests without any decrease in reactivity occurring with increasing age. In the hospitalized group, only 62 per cent of the ward and 63 per cent of the ICU patients reacted to the same skin tests. All (8/8) anergic ICU patients tested after discharge regained normal reactivity. Acute illness but not increasing age will impair the delayed hypersensitivity skin test response.
Authors:
J Grossman; J Baum; J Gluckman; J Fusner; J J Condemi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  55     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-07-02     Completed Date:  1975-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-75     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease*
Adult
Aged
Aging*
Antigens
Antigens, Fungal
Antigens, Viral
Culicidae / immunology
Female
Humans
Hypersensitivity, Delayed / immunology*
Lectins / pharmacology
Lymphocyte Activation
Male
Middle Aged
Mitosporic Fungi / immunology
Mumps virus / immunology
Myocardial Infarction / immunology
Pulmonary Embolism / immunology
Skin Tests
Staphylococcal Toxoid
Streptodornase and Streptokinase / immunology
Trichophyton / immunology
Tuberculin
Chemical
Reg. No./Substance:
0/Antigens; 0/Antigens, Fungal; 0/Antigens, Viral; 0/Lectins; 0/Staphylococcal Toxoid; 0/Tuberculin; EC 3.-/Streptodornase and Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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