Document Detail

The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration.
MedLine Citation:
PMID:  1559309     Owner:  NLM     Status:  MEDLINE    
The influence of age on the systemic absorption and disposition of bupivacaine following epidural administration in 20 male patients (22 to 81 years) was examined using a stable isotope method to determine whether pharmacokinetics play a role in age-related pharmacodynamic changes seen with the drug. After epidural bupivacaine administration a deuterium-labelled analogue was administered intravenously. Bi- and triexponential functions were fitted to plasma concentration-time data of deuterium-labelled bupivacaine. The systemic absorption was described by 2 parallel first-order absorption processes. The upper level of analgesia and the duration of analgesia at dermatome T-12 increased with age (r = 0.68, p less than 0.001; r = 0.56, p less than 0.01, respectively). The time to maximal caudad spread of analgesia and the time to onset of motor block decreased with age (r = -0.76, p less than 0.0001; r = -0.72, p less than 0.001, respectively). Age did not influence systemic absorption or disposition of bupivacaine. We conclude that the changes in the clinical profile of bupivacaine with age are not due to altered pharmacokinetics, but may be related to changes in the pharmacodynamics of the drug.
B T Veering; A G Burm; A A Vletter; R P van den Heuvel; W Onkenhout; J Spierdijk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacokinetics     Volume:  22     ISSN:  0312-5963     ISO Abbreviation:  Clin Pharmacokinet     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606849     Medline TA:  Clin Pharmacokinet     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Department of Anaesthesiology, University Hospital, Leiden, The Netherlands.
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MeSH Terms
Aged, 80 and over
Aging / physiology*
Anesthesia, Epidural
Bupivacaine / blood,  pharmacokinetics*
Middle Aged
Reg. No./Substance:

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