| The effect of age on the relative potency of midazolam and diazepam for sedation in upper gastrointestinal endoscopy. | |
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MedLine Citation:
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PMID: 2324478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diazepam and midazolam are considered safe and effective sedative agents for diagnostic procedures. However, there have been recent reports of deaths in older patients receiving midazolam for sedation. We examined the relative potency of diazepam compared with midazolam as a function of age in two large groups of patients receiving intravenous benzodiazepines for upper gastrointestinal endoscopy. While midazolam and diazepam are approximately equivalent before age 60, after age 60 the relative potency of midazolam compared with diazepam increases markedly. The rapid decline in dose necessary to sedate older patients with midazolam may explain deaths occurring in older patients who have received this drug. Until this problem receives definitive study, we advise that diazepam be preferred over midazolam for intravenous sedation in patients over 60. |
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Authors:
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S G Scholer; D F Schafer; J F Potter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 12 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-18 Completed Date: 1990-05-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68105. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Cause of Death Diazepam / administration & dosage*, adverse effects Endoscopy* Female Gastrointestinal Diseases / diagnosis* Humans Injections, Intravenous Male Midazolam / administration & dosage*, adverse effects Middle Aged Regression Analysis Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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439-14-5/Diazepam; 59467-70-8/Midazolam |
| Comments/Corrections | |
Comment In:
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J Clin Gastroenterol. 1990 Dec;12(6):716-7
[PMID:
2266257
]
J Clin Gastroenterol. 1991 Feb;13(1):117-8 [PMID: 2053965 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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