Document Detail

The effect of age on the relative potency of midazolam and diazepam for sedation in upper gastrointestinal endoscopy.
MedLine Citation:
PMID:  2324478     Owner:  NLM     Status:  MEDLINE    
Diazepam and midazolam are considered safe and effective sedative agents for diagnostic procedures. However, there have been recent reports of deaths in older patients receiving midazolam for sedation. We examined the relative potency of diazepam compared with midazolam as a function of age in two large groups of patients receiving intravenous benzodiazepines for upper gastrointestinal endoscopy. While midazolam and diazepam are approximately equivalent before age 60, after age 60 the relative potency of midazolam compared with diazepam increases markedly. The rapid decline in dose necessary to sedate older patients with midazolam may explain deaths occurring in older patients who have received this drug. Until this problem receives definitive study, we advise that diazepam be preferred over midazolam for intravenous sedation in patients over 60.
S G Scholer; D F Schafer; J F Potter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  12     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-18     Completed Date:  1990-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-7     Citation Subset:  IM    
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68105.
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MeSH Terms
Age Factors
Aged, 80 and over
Cause of Death
Diazepam / administration & dosage*,  adverse effects
Gastrointestinal Diseases / diagnosis*
Injections, Intravenous
Midazolam / administration & dosage*,  adverse effects
Middle Aged
Regression Analysis
Retrospective Studies
Reg. No./Substance:
439-14-5/Diazepam; 59467-70-8/Midazolam
Comment In:
J Clin Gastroenterol. 1990 Dec;12(6):716-7   [PMID:  2266257 ]
J Clin Gastroenterol. 1991 Feb;13(1):117-8   [PMID:  2053965 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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