Document Detail


The effect of age on the pharmacokinetics of the opioid antagonist nalmefene.
MedLine Citation:
PMID:  8877019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The disposition of nalmefene was evaluated in young and elderly normal healthy volunteers. Subjects received either a single 1 mg (n = 18 young; n = 11 elderly) or 2 mg (n = 8 young; n = 15 elderly) intravenous bolus dose of nalmefene. 2. Following the administration of nalmefene, the initial plasma concentrations were significantly higher in elderly vs young subjects. The higher concentrations were the result of the 30 to 40% smaller central compartment apparent volume of distribution that was observed in the elderly subjects as compared with the young volunteers (2.8 +/- 1.1 vs 3.9 +/- 1.11 kg-1 for 1 mg dose). The elderly volunteers also had a significantly shorter distributional half-life (t1/2 lambda 1) than young volunteers (0.7 +/- 0.7 vs 1.3 +/- 0.8 h for 1 mg dose). No significant differences between groups were observed for the elimination half-life, clearance or steady-state apparent volume of distribution. 3. Although transiently higher nalmefene plasma concentrations were observed in the elderly immediately following drug administration, there was no association between this observation and adverse events. We conclude that no dosage alteration is warranted in elderly patients.
Authors:
R F Frye; G R Matzke; N S Jallad; J A Wilhelm; G B Bikhazi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  42     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2009-10-02    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, PA 15261, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Humans
Middle Aged
Naltrexone / analogs & derivatives*,  pharmacokinetics
Narcotic Antagonists / pharmacokinetics*
Chemical
Reg. No./Substance:
0/Narcotic Antagonists; 16590-41-3/Naltrexone; 55096-26-9/nalmefene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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