Document Detail

The effect of age on pathways of drug metabolism in human liver.
MedLine Citation:
PMID:  6334986     Owner:  NLM     Status:  MEDLINE    
The effect of age on some important pathways of drug metabolism in human liver biopsy specimens was examined. Five parameters were investigated: two microsomal mono-oxygenases; aldrin epoxidation and 7-ethoxycoumarin-O-de-ethylation; microsomal protein recovery; epoxide hydrolase activity and concentrations of reduced gluthatione. No correlation was observed between age and any of these measurements. It is concluded that, contrary to conventionally held views, impaired clearance of some drugs in the elderly is unlikely to be due to decreased hepatic microsomal enzyme specific activity. Any increase in adverse drug reactions in the elderly liver is unlikely to be due to impaired detoxification of reactive metabolites.
K W Woodhouse; E Mutch; F M Williams; M D Rawlins; O F James
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Age and ageing     Volume:  13     ISSN:  0002-0729     ISO Abbreviation:  Age Ageing     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-01-29     Completed Date:  1985-01-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375655     Medline TA:  Age Ageing     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  328-34     Citation Subset:  IM    
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MeSH Terms
7-Alkoxycoumarin O-Dealkylase
Epoxide Hydrolases / metabolism
Glutathione / metabolism
Microsomes, Liver / enzymology*
Middle Aged
Mixed Function Oxygenases / metabolism
Oxygenases / metabolism
Pharmaceutical Preparations / metabolism*
Reg. No./Substance:
0/Pharmaceutical Preparations; 70-18-8/Glutathione; EC 1.-/Mixed Function Oxygenases; EC 1.-/aldrin epoxidase; EC 1.13.-/Oxygenases; EC 1.14.13.-/7-Alkoxycoumarin O-Dealkylase; EC 3.3.2.-/Epoxide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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