| The effect of age on the microheterogeneous pattern of human myelin basic protein. | |
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MedLine Citation:
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PMID: 6207079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dry weight, total basic protein and myelin basic protein (MBP) in human corpus callosum tissue were found to be significantly reduced with age, confirming other reports. The heterogeneous patterns of the MBP samples were investigated and could be classified into three groups: a normal one with peak 1 larger than peak 3; an old-age pattern with peak 1 smaller than peak 3; and a pathological pattern with peak 1 greatly reduced. Because peak 1 is the only one which is significantly reduced with age, it is suggested that future investigations could be simplified. The physiological and pathophysiological role of MBP heterogeneity is discussed. |
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Authors:
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B Riederer; C G Honegger; H J Tobler; J Ulrich |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gerontology Volume: 30 ISSN: 0304-324X ISO Abbreviation: Gerontology Publication Date: 1984 |
Date Detail:
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Created Date: 1984-11-01 Completed Date: 1984-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7601655 Medline TA: Gerontology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 234-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging* Chromatography, Ion Exchange Corpus Callosum / metabolism*, physiology Electrophoresis, Polyacrylamide Gel Humans Middle Aged Myelin Basic Proteins / analysis, physiology* Myelin Proteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Myelin Basic Proteins; 0/Myelin Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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