Document Detail


The effect of age on the microheterogeneous pattern of human myelin basic protein.
MedLine Citation:
PMID:  6207079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dry weight, total basic protein and myelin basic protein (MBP) in human corpus callosum tissue were found to be significantly reduced with age, confirming other reports. The heterogeneous patterns of the MBP samples were investigated and could be classified into three groups: a normal one with peak 1 larger than peak 3; an old-age pattern with peak 1 smaller than peak 3; and a pathological pattern with peak 1 greatly reduced. Because peak 1 is the only one which is significantly reduced with age, it is suggested that future investigations could be simplified. The physiological and pathophysiological role of MBP heterogeneity is discussed.
Authors:
B Riederer; C G Honegger; H J Tobler; J Ulrich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gerontology     Volume:  30     ISSN:  0304-324X     ISO Abbreviation:  Gerontology     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  234-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging*
Chromatography, Ion Exchange
Corpus Callosum / metabolism*,  physiology
Electrophoresis, Polyacrylamide Gel
Humans
Middle Aged
Myelin Basic Proteins / analysis,  physiology*
Myelin Proteins / analysis
Chemical
Reg. No./Substance:
0/Myelin Basic Proteins; 0/Myelin Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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