Document Detail

The effect of age on glucose-modulated cerebral agonal glycolytic rates measured in vivo by 1H NMR spectroscopy.
MedLine Citation:
PMID:  1805155     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the effect of plasma glucose concentration on cerebral agonal glycolytic rates in piglets of different ages. Twenty-four piglets were divided into four different age groups corresponding to 113, 121, 128, and 145 d postconception (normal gestation = 115 d). For each group the agonal glycolytic rate was measured by monitoring the rate of cerebral lactate accumulation after total ischemia. Ischemia was induced by cardiac arrest, and the rate of lactate formation was measured in vivo using proton nuclear magnetic resonance spectroscopy. Before cardiac arrest, the blood plasma glucose concentration for individual piglets was adjusted to a specific value in the range 1-30 mM. The dependence of agonal glycolytic rate upon blood glucose concentration was analyzed for each age group, using the Michaelis-Menten equation to evaluate Vmax, the maximal rate of glucose utilization, and Km the concentration of plasma glucose at which the half maximal rate of utilization occurs. Vmax for the two youngest age groups of piglets had significantly different (p less than 0.05) values compared with each other (1.38 +/- 0.17 and 1.92 +/- 0.64 mumol.g-1.min-1, respectively) and with the two older groups of animals (2.99 +/- 0.52 and 3.42 +/- 0.65 mumol.g-1.min-1, respectively). The Km values determined for the two youngest age groups (0.79 +/- 0.70 and 1.79 +/- 0.33 mM, respectively) also were significantly lower than for the two older age groups (4.96 +/- 2.90 and 4.82 +/- 2.96 mM, respectively). We conclude that throughout the first 2 wk of life there are marked increases in the cerebral glycolytic capacity.(ABSTRACT TRUNCATED AT 250 WORDS)
R J Corbett; A R Laptook; J I Ruley; D Garcia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  30     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-05-04     Completed Date:  1992-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  579-86     Citation Subset:  IM    
Ralph Rogers and Mary Nell Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235-9085.
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MeSH Terms
Age Factors
Animals, Newborn
Blood Glucose / metabolism*
Brain / growth & development,  metabolism*
Brain Injuries / etiology
Brain Ischemia / complications,  metabolism
Hyperglycemia / complications,  metabolism
Lactates / metabolism
Lactic Acid
Magnetic Resonance Spectroscopy
Swine, Miniature
Grant Support
2 S07 RR 07175-13/RR/NCRR NIH HHS; 5-P41-RR02584/RR/NCRR NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 50-21-5/Lactic Acid

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