Document Detail

The effect of adrenaline on desflurane-induced prolonged QTc interval: a randomized double-blind trial.
MedLine Citation:
PMID:  23771541     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: We investigated the effect of adrenaline on desflurane-induced prolonged corrected QT (QTc) interval.
PATIENTS AND METHODS: Sixty-two adult patients scheduled for nasal surgery were included. Following intubation, packs soaked in physiological saline were used for Group C (control) and packs soaked in adrenaline (1/200,000, 5 ml) were used for Groups A1 and A2. Group A2 was given desflurane simultaneously with nasal packing; other groups were given desflurane following removal of the packs. QTc interval was evaluated at 9 periods, from prior to induction of anaesthesia to postoperative first hour.
RESULTS: QTc interval was significantly reduced in Groups A1 and A2 compared to Group C during packaging (p < 0.001, p < 0.05 respectively), while QTc interval gradually prolonged after desflurane administration (p < 0.05 in Groups C compared to Groups A1 and A2). Patients did not develop arrhythmia.
CONCLUSIONS: Our findings show that desflurane caused progressive prolongation of the QTc interval, and adrenaline shortened QTc interval only at application period of packs.
A Bestas; O Hanbeyoglu; E Keles; M K Bayar
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European review for medical and pharmacological sciences     Volume:  17     ISSN:  1128-3602     ISO Abbreviation:  Eur Rev Med Pharmacol Sci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2013-09-04     Revised Date:  2013-12-06    
Medline Journal Info:
Nlm Unique ID:  9717360     Medline TA:  Eur Rev Med Pharmacol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1523-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Inhalation / pharmacology*
Blood Pressure / drug effects
Double-Blind Method
Electrocardiography / drug effects*
Epinephrine / pharmacology*
Heart Rate / drug effects
Isoflurane / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Anesthetics, Inhalation; 57041-67-5/desflurane; CYS9AKD70P/Isoflurane; YKH834O4BH/Epinephrine
Comment In:
Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2552   [PMID:  24089239 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficacy and cost effectiveness of rapid on site examination (ROSE) in management of patients with m...
Next Document:  Effects of glutamine-supplemented enteral or parenteral nutrition on apoptosis of intestinal mucosal...