Document Detail

The effect of adjunctive Mitomycin C in Ahmed glaucoma valve implantation.
MedLine Citation:
PMID:  15751236     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effectiveness and safety of adjunctive mitomycin C (MMC) in Ahmed glaucoma valve (AGV) implantation for refractory glaucoma. METHODS: Twenty-two eyes of 22 patients who underwent AGV implantation with adjunctive MMC (0.5 mg/ml) for 3 minutes (Group A) were compared to a control group of 26 eyes of 26 patients (Group B) who received AGV implantation without MMC. Nine patients were female and 13 patients were male in Group A and 11 patients were female and 15 patients were male in Group B. The mean age was 56 years ranging from 13 to 77 in Group A and 58 ranging from 14 to 71 years in Group B. Success was defined as an intraocular pressure (IOP) between 4 and 21 mmHg with or without glaucoma medication and with no additional glaucoma surgery, phthisis, or loss of light perception. RESULTS: The probability of success at 1 year was 86.36% and 80.76% in Group A and Group B, respectively. The number of glaucoma medications decreased from 2.82 to 0.56 in Group A and from 2.65 to 0.73 in Group B. Postoperative hypotony as an early complication was higher in Group A (31.81% in Group A and 15.38% in Group B). As a late postoperative complication, tube exposure developed in 3 patients (13.63%) in Group A and no such complication was seen in Group B. There was no statistically significant difference in success and complication rates between the two groups (p>0.05). CONCLUSIONS: Although adjunctive MMC in AGV implantation is safe and effective, it may not offer a better chance of surgical success compared with AGV implantation without MMC.
E Kurnaz; A Kubaloglu; Y Yilmaz; A Koytak; Y Ozertürk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  15     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Department of Ophthalmology, Education and Research Hospital, Istanbul - Turkey.
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MeSH Terms
Antibiotics, Antineoplastic / therapeutic use*
Chemotherapy, Adjuvant
Conjunctiva / drug effects
Fibrosis / prevention & control
Glaucoma / drug therapy*,  surgery*
Glaucoma Drainage Implants*
Intraocular Pressure
Middle Aged
Mitomycin / therapeutic use*
Postoperative Complications
Prosthesis Implantation
Sclera / drug effects
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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