| The effect of adenotonsillectomy on serum insulin like growth factors and the adenoid/nasopharynx ratio in pediatric patients: a blind, prospective clinical study. | |
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MedLine Citation:
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PMID: 22155086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Obstructive adenoid and tonsillar hyperplasia may present with retardation of growth. An adenoid-nasopharynx (A/N) ratio determined by means of lateral cephalometric radiographs has long been used as a diagnostic tool in the assessment of adenoid size. This study was designed to investigate the effect of adenotonsillectomy on insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels and correlation between A/N ratio and IGF-I and IGFBP-3 levels. METHODS: Patients (n=48) that had been operated on our clinic with a diagnosis of adenotonsillar hypertrophy between July 2009 and January 2010 were included in the study. The routine ear-nose and throat examination was done in all patients. Blood samples were taken, and lateral cephalometric radiographs were obtained preoperatively and repeated at 6-9 months (mean 7.2 ± 1.0 mo) following tonsillectomy and adenoidectomy. The chemiluminescent enzyme-linked immunosorbent method was used to IGF-I and IGFBP-3 levels. Each cephalometric radiograph was evaluated by a blinded radiologist. The A/N ratio was calculated using the Fujioka method. RESULTS: When the preoperative and postoperative results were compared, a statistically significant increase in serum IGF-I and IGFBP-3 and a decreased A/N ratio were found. However, although correlation between the Δ(preoperative-postoperative difference) IGFBP-3 and ΔA/N ratio was 40%, it was not statistically significant. Additionally, no statistically significant correlation between the ΔIGF-I and ΔA/N ratio was found. CONCLUSIONS: The results of the present study indicate that adenotonsillectomy could result in the relief of nasopharyngeal obstruction and have a positive effect on growth in children by decreasing the A/N ratio and increasing IGF-I and IGFBP-3. There was no correlation between the ΔA/N ratio and ΔIGF-I and ΔIGFBP-3 levels. |
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Authors:
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Arzu Tatlıpınar; Sacide Atalay; Erkan Esen; Gökalp Yılmaz; Sema Köksal; Tanju Gökçeer |
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Publication Detail:
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Type: Clinical Trial; In Vitro; Journal Article Date: 2011-12-10 |
Journal Detail:
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Title: International journal of pediatric otorhinolaryngology Volume: 76 ISSN: 1872-8464 ISO Abbreviation: Int. J. Pediatr. Otorhinolaryngol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-17 Completed Date: 2012-05-22 Revised Date: 2012-05-31 |
Medline Journal Info:
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Nlm Unique ID: 8003603 Medline TA: Int J Pediatr Otorhinolaryngol Country: Ireland |
Other Details:
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Languages: eng Pagination: 248-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Haydarpasa Numune Research and Training Hospital, 1st ENT Clinic, Uskudar, Istanbul, Turkey. arzutatli@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoidectomy
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methods* Airway Obstruction / diagnosis, etiology Body Height Cephalometry / methods Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Growth Disorders / prevention & control Humans Insulin-Like Growth Factor Binding Protein 3 / blood* Insulin-Like Growth Factor I / metabolism* Male Nasopharynx / pathology*, radiography Prospective Studies Single-Blind Method Sleep Apnea Syndromes / diagnosis, etiology Tonsillectomy / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
Comment In:
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Int J Pediatr Otorhinolaryngol. 2012 May;76(5):762-3; author reply 763-4
[PMID:
22390905
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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