Document Detail

The effect of adenotonsillectomy on serum insulin like growth factors and the adenoid/nasopharynx ratio in pediatric patients: a blind, prospective clinical study.
MedLine Citation:
PMID:  22155086     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Obstructive adenoid and tonsillar hyperplasia may present with retardation of growth. An adenoid-nasopharynx (A/N) ratio determined by means of lateral cephalometric radiographs has long been used as a diagnostic tool in the assessment of adenoid size. This study was designed to investigate the effect of adenotonsillectomy on insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels and correlation between A/N ratio and IGF-I and IGFBP-3 levels.
METHODS: Patients (n=48) that had been operated on our clinic with a diagnosis of adenotonsillar hypertrophy between July 2009 and January 2010 were included in the study. The routine ear-nose and throat examination was done in all patients. Blood samples were taken, and lateral cephalometric radiographs were obtained preoperatively and repeated at 6-9 months (mean 7.2 ± 1.0 mo) following tonsillectomy and adenoidectomy. The chemiluminescent enzyme-linked immunosorbent method was used to IGF-I and IGFBP-3 levels. Each cephalometric radiograph was evaluated by a blinded radiologist. The A/N ratio was calculated using the Fujioka method.
RESULTS: When the preoperative and postoperative results were compared, a statistically significant increase in serum IGF-I and IGFBP-3 and a decreased A/N ratio were found. However, although correlation between the Δ(preoperative-postoperative difference) IGFBP-3 and ΔA/N ratio was 40%, it was not statistically significant. Additionally, no statistically significant correlation between the ΔIGF-I and ΔA/N ratio was found.
CONCLUSIONS: The results of the present study indicate that adenotonsillectomy could result in the relief of nasopharyngeal obstruction and have a positive effect on growth in children by decreasing the A/N ratio and increasing IGF-I and IGFBP-3. There was no correlation between the ΔA/N ratio and ΔIGF-I and ΔIGFBP-3 levels.
Arzu Tatlıpınar; Sacide Atalay; Erkan Esen; Gökalp Yılmaz; Sema Köksal; Tanju Gökçeer
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Publication Detail:
Type:  Clinical Trial; In Vitro; Journal Article     Date:  2011-12-10
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  76     ISSN:  1872-8464     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-05-22     Revised Date:  2012-05-31    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Haydarpasa Numune Research and Training Hospital, 1st ENT Clinic, Uskudar, Istanbul, Turkey.
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MeSH Terms
Adenoidectomy / methods*
Airway Obstruction / diagnosis,  etiology
Body Height
Cephalometry / methods
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Growth Disorders / prevention & control
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / metabolism*
Nasopharynx / pathology*,  radiography
Prospective Studies
Single-Blind Method
Sleep Apnea Syndromes / diagnosis,  etiology
Tonsillectomy / methods*
Treatment Outcome
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I
Comment In:
Int J Pediatr Otorhinolaryngol. 2012 May;76(5):762-3; author reply 763-4   [PMID:  22390905 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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