Document Detail


The effect of acute psychological stress on QT dispersion in patients with coronary artery disease.
MedLine Citation:
PMID:  19719496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: An acute psychological stress can precipitate ventricular arrhythmias and sudden cardiac death in patients with coronary artery disease (CAD). However, the physiologic mechanisms by which these effects occur are not entirely clear. Mental stress-induced myocardial ischemia occurs in a significant percentage of the CAD population. It is unknown if the proarrhythmic effects of psychological stress are mediated through the development of myocardial ischemia.
OBJECTIVES: To examine the effects of psychological stress on QT dispersion (QTd) among CAD patients and whether these effects are mediated via the development of myocardial ischemia.
METHODS: Psychological stress was induced using a public speaking task. Twelve-lead electrocardiograms (ECG) were recorded at rest, during mental stress, and during recovery. QTd was calculated as the difference between the longest and the shortest QT interval in the 12-lead ECG. Rest-stress myocardial perfusion imaging was also performed to detect mental stress-induced myocardial ischemia.
RESULTS: Mental stress induced a significant increase in QTd compared to the resting condition (P < 0.001). This effect persisted beyond the first 10 minutes of recovery (P < 0.001). QTd was significantly associated with the development of mental stress ischemia with ischemic patients having significantly higher QTd during mental stress than nonischemic patients (P = 0.006). This finding remained significant after controlling for possible confounding factors (P = 0.01).
CONCLUSION: An acute psychological stress induces a significant increase in QTd, which persists for more than 10 minutes after the cessation of the stressor. This effect seems to be, at least partially, mediated by the development of mental stress-induced myocardial ischemia.
Authors:
Mustafa Hassan; April Mela; Qin Li; Babette Brumback; Roger B Fillingim; Jamie B Conti; David S Sheps
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  32     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-11-12     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1178-83     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida, USA. mustafa.hassan@medicine.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / complications*,  diagnosis*
Coronary Artery Disease / complications*,  diagnosis*
Electrocardiography / methods*
Female
Heart Rate
Humans
Male
Middle Aged
Stress, Psychological / complications*,  diagnosis*
Grant Support
ID/Acronym/Agency:
HL 070265/HL/NHLBI NIH HHS; HL 072059/HL/NHLBI NIH HHS; R01 HL070265-05/HL/NHLBI NIH HHS; R01 HL072059-05/HL/NHLBI NIH HHS
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