Document Detail

The effect of acute normovolemic hemodilution on homologous blood requirements and total estimated red blood cell volume lost.
MedLine Citation:
PMID:  9181163     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute normovolemic hemodilution combined with retransfusion is one of the various techniques proposed to avoid homologous blood transfusion in cardiac surgery. The purpose of the present paper is to study the effect of the volume of autologous blood collected pre-cardiopulmonary bypass (CPB) on homologous blood requirements and total estimated red blood cell (RBC) volume lost in coronary artery bypass grafting (CABG) surgery. METHODS: Following induction of anesthesia, sequestration of one (5-8 ml/kg; Group I, n = 14) or two units (12-15 ml/kg; Group II, n = 14) of fresh autologous blood was performed under electrocardiographic and hemodynamic control. Group III (n = 14) was designated as the control group. Autologous blood was reinfused at the conclusion of CPB. RESULTS: The use of homologous blood in the study groups was significantly less than in the control group. High-volume phlebotomy did not make a significant difference in the requirement of the homologous blood, while causing a mild increase in the total estimated RBC volume lost. No significant differences could be demonstrated in preoperative, post-CPB and discharge hematocrit levels and postoperative blood drainage between the groups. CONCLUSION: Acute intraoperative hemodilution with high- and low-volume phlebotomy reduced the homologous blood requirements similarly regardless of the amount of phlebotomy.
S Kahraman; H Altunkaya; B Celebioğlu; M Kanbak; I Paşaoğlu; K Erdem
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  41     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  614-7     Citation Subset:  IM    
Department of Anaesthesiology and Reanimation, Hacettepe University Medical School, Ankara, Turkey.
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MeSH Terms
Blood Loss, Surgical / physiopathology*,  prevention & control
Blood Transfusion*
Blood Transfusion, Autologous
Cardiopulmonary Bypass
Coronary Artery Bypass
Erythrocyte Indices*
Middle Aged

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