Document Detail


The effect of an acute increase in renal perfusion pressure on sodium transport in the rat kidney.
MedLine Citation:
PMID:  975457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used micropuncture techniques to examine the intrarenal response to an acute elevation of the renal perfusion pressure. In one series of studies (epinephrine, group I) the renal perfusion pressure was acutely increased by intravenous epinephrine infusion; in another series, by bilateral carotid occlusion and vagotomy. A third series of studies (epinephrine, group II) was performed identically to the epinephrine, group I, studies except that the renal perfusion pressure was held constant during the epinephrine infusion by suprarenal aortic constriction. After epinephrine infusion (group I) and following bilateral carotid occlusion and vagotomy the renal perfusion pressure increased, from 119 +/- 1.0 (SEM) to 166 +/- 1.85 mm Hg and from 122 +/- 5.9 to 168 +/- 3.1 mm Hg, respectively. Fractional sodium excretion rose from 2.31 +/- 0.34% to 5.09 +/- 0.58% (P less than 0.001) after epinephrine and from 1.80 +/- 0.71 to 6.40 +/- 1.0% (P less than 0.01) following carotid occlusion and vagotomy. In neither study, however, did we find that the increase in renal perfusion pressure changed the glomerular filtration rate (GFR) (both kidneys) or fractional sodium delivery from the superficial cortical late distal tubule. Furthermore, we found that epinephrine infusion at a constant renal perfusion pressure (epinephrine, group II) did not affect fractional sodium excretion, although a small, but significant, decrease in the GFR and sodium delivery from the superficial late distal tubule occurred. These data suggest that the natriuresis which follows an acute elevation of the renal perfusion pressure cannot be attributed to enhanced sodium delivery from superficial nephrons but must result from (1) inhibition of sodium reabsorption in inner cortical nephrons or (2) an effect on sodium transport in the collecting system.
Authors:
R T Kunau; N H Lameire
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  39     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Arterial Occlusive Diseases / metabolism
Biological Transport
Blood Pressure / drug effects
Carotid Artery Diseases / metabolism
Epinephrine / pharmacology
Glomerular Filtration Rate / drug effects
Hypertension / chemically induced,  metabolism*
Inulin / metabolism
Kidney / blood supply
Kidney Concentrating Ability / drug effects
Kidney Tubules / metabolism*
Kidney Tubules, Distal / metabolism*
Male
Natriuresis / drug effects
Rats
Regional Blood Flow
Sodium / metabolism*
Vagotomy
Chemical
Reg. No./Substance:
51-43-4/Epinephrine; 7440-23-5/Sodium; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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