Document Detail

The effect of acute hypoxemia on coronary arterial dimensions in patients with coronary artery disease.
MedLine Citation:
PMID:  19092242     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the influence of acute hypoxemia on the dimensions of diseased and nondiseased coronary arterial segments in humans. METHODS: In 18 subjects (age 53 +/- 8 years) with known or suspected coronary artery disease, quantitative coronary angiography was performed before and after being randomly assigned to breathing (1) an inspired oxygen concentration (fraction of inspired oxygen, FIO2) of 21% (room air, RA) for 20 min (n = 4, controls) or (2) an FIO2 of 15 and 10% for 10 min each (corresponding to altitudes of 2,500 and 5,500 m, respectively; n = 14). RESULTS: In the control subjects, no hemodynamic, oximetric or angiographic variable changed. In the 14 study subjects, the arterial partial pressure of oxygen averaged 85 +/- 13 mm Hg on RA, 65 +/- 15 mm Hg on 15% FIO2 and 44 +/- 13 mm Hg on 10% FIO2. Average arterial segment diameter was 2.52 +/- 0.63 mm on RA, 2.55 +/- 0.62 mm on 15% FIO2 (not significant vs. RA) and 2.66 +/- 0.66 mm on 10% FIO2 (p < 0.001 vs. RA). The increase in coronary arterial diameter with 10% FIO2 occurred only in normal segments (2.74 +/- 0.64 vs. 2.97 +/- 0.64 mm; p < 0.001), but not in diseased segments (2.34 +/- 0.57 vs. 2.38 +/- 0.55 mm; not significant). CONCLUSIONS: In humans, severe hypoxemia induces vasodilation of angiographically normal coronary arterial segments, whereas it causes no change in diseased segments.
Armin Arbab-Zadeh; Benjamin D Levine; Jeffrey C Trost; Richard A Lange; Ellen C Keeley; L David Hillis; Joaquin E Cigarroa
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-12-18
Journal Detail:
Title:  Cardiology     Volume:  113     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Cardiology Division, Johns Hopkins University, 600 N. Wolfe St/Blalock 524, Baltimore, MD 21287-0409, USA.
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MeSH Terms
Acute Disease
Anoxia / drug therapy*,  physiopathology,  radiography*
Coronary Angiography
Coronary Artery Disease / physiopathology,  radiography*
Coronary Circulation / drug effects,  physiology*
Heart Catheterization
Middle Aged
Oxygen / administration & dosage*,  blood
Severity of Illness Index
Vasodilation / drug effects,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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