Document Detail


The effect of acute exercise on endothelial progenitor cells is attenuated in chronic heart failure.
MedLine Citation:
PMID:  21290145     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Exercise training improves endothelial function in patients with chronic heart failure (CHF) through functional enhancement of circulating angiogenic cells and increased numbers of circulating endothelial progenitor cells (EPC). In contrast to healthy subjects, an immediate effect of acute exercise on CD34(+)/KDR(+) EPC is absent in CHF. Whether this reflects an attenuated or rather delayed mobilization, is addressed in the present study by measuring CD34(+)/KDR(+) EPC over a longer time period post-exercise. Seven CHF patients and eight healthy subjects (HS; 4 young and 4 age-matched subjects) underwent graded exercise testing (GXT). Venous blood was sampled before and 10, 30, and 60 min, 2, 4, 8, 12, 24 and 48 h following GXT to determine numbers of circulating CD34(+)/KDR(+) EPC (flow cytometry) and serum levels of stromal cell-derived factor (SDF)-1α (ELISA). In both HS groups, CD34(+)/KDR(+) EPC numbers increased within 10 min following GXT and remained elevated for up to 2 h. In CHF patients, the initial increase was small and normalized within 30 min. Evolution of CD34(+)/KDR(+) EPC numbers over time following GXT overall was attenuated in CHF versus HS (p = 0.036). Exercise considerably influenced SDF-1α levels over time (p = 0.0008), without a relation to the changes in CD34(+)/KDR(+) EPC. The immediate effect of acute exercise on CD34(+)/KDR(+) EPC numbers is not delayed, but significantly attenuated in CHF patients compared to HS.
Authors:
Emeline M Van Craenenbroeck; Luc Bruyndonckx; Christophe Van Berckelaer; Vicky Y Hoymans; Christiaan J Vrints; Viviane M Conraads
Related Documents :
21535455 - Voluntary exercise induces adult hippocampal neurogenesis and bdnf expression in a rode...
8072065 - Energy demands in competitive soccer.
18714215 - Reliability of the reactive strength index and time to stabilization during depth jumps.
12741875 - Effect of a submaximal half-squats warm-up program on vertical jumping ability.
11174715 - Topical application of antiangiogenic agent agm-1470 suppresses anastomotic intimal hyp...
8931835 - Exaggerated blood pressure response to maximal exercise in endurance-trained individuals.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-3
Journal Detail:
Title:  European journal of applied physiology     Volume:  -     ISSN:  1439-6327     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium, Emeline.Vancraenenbroeck@ua.ac.be.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy...
Next Document:  PRBP plays a role in plastid ribosomal RNA maturation and chloroplast biogenesis in Nicotiana bentha...