| The effect of acute angiotensin II blockade on renal function in rats with reduced renal mass. | |
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MedLine Citation:
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PMID: 7861724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of acute Ang II blockade on renal function in rats with reduced nephron number was assessed in micropuncture studies. The Ang II receptor blocker, losartan, was administered at a dose of 10 mg i.v. at two intervals following five-sixths renal ablation. At eight weeks following ablation, Ang II blockade (Ang IIX) increased sodium excretion [UNa V, Ang IIX 2.2 +/- 0.4 microEq/min; time control (TC) 1.0 +/- 0.3 microEq/min; P < 0.05] but did not reduce mean arterial pressure (AP, Ang IIX 142 +/- 6 mm Hg; TC 151 +/- 6 mmHg), glomerular transcapillary pressure (delta P, Ang IIX 50 +/- 1 mm Hg; TC 50 +/- 1 mm Hg), or urine albumin excretion (UAlb V: Ang IIX 149 +/- 18 micrograms/min; TC 168 +/- 20 micrograms/min). Similarly, at two weeks following ablation, Ang II blockade increased UNa V (Ang IIX 2.8 +/- 0.4 microEq/min; TC 0.5 +/- 0.2 microEq/min; P < 0.05) without reducing AP (Ang IIX 132 +/- 6 mm Hg; TC 140 +/- 7 mm Hg), delta P (Ang IIX 50 +/- 3 mm Hg; TC 48 +/- 2 mm Hg), or UAlb V (Ang IIX 32 +/- 3 micrograms/min; TC 36 +/- 10 micrograms/min). These findings indicate that within the remant kidney, Ang II promotes sodium retention but does not have an acutely reversible effect on glomerular pressure or permselectivity. |
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Authors:
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K Baboolal; T W Meyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Kidney international Volume: 46 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-03-21 Completed Date: 1995-03-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 980-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Palo Alto VAMC, California. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria
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physiopathology Angiotensin II / antagonists & inhibitors*, physiology Animals Biphenyl Compounds / administration & dosage, pharmacology Blood Pressure / drug effects, physiology Hypertension, Renal / etiology, physiopathology Imidazoles / administration & dosage, pharmacology Kidney / drug effects, pathology, physiopathology* Losartan Male Natriuresis / drug effects, physiology Nephrectomy Punctures Rats Rats, Wistar Tetrazoles / administration & dosage, pharmacology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK 40800/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biphenyl Compounds; 0/Imidazoles; 0/Tetrazoles; 11128-99-7/Angiotensin II; 114798-26-4/Losartan |
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