| The effect of acetyl-L-carnitine administration on persons with Down syndrome. | |
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MedLine Citation:
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PMID: 16621446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since previous investigations reported improvements in cognition of patients with dementia after acetyl-L-carnitine therapy and since there is an increased risk for persons with Down syndrome to develop Alzheimer disease, this study was designed to investigate the effect of acetyl-L-carnitine administration on neurological, intellectual, and social functions in adults with Down syndrome. In this double-blind study we enrolled 40 individuals with Down syndrome and administered acetyl-L-carnitine to the study group during a six months period. Specified examinations and psychological tests were given to persons in both the study and control groups at the start of the investigation and at 3, 6, and 9 months. A detailed analysis of the data revealed that acetyl-L-carnitine administration did not enhance central nervous system functions and that it did not benefit persons with Down syndrome. |
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Authors:
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Siegfried M Pueschel |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2006-04-18 |
Journal Detail:
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Title: Research in developmental disabilities Volume: 27 ISSN: 0891-4222 ISO Abbreviation: Res Dev Disabil Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-10-03 Completed Date: 2007-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709782 Medline TA: Res Dev Disabil Country: United States |
Other Details:
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Languages: eng Pagination: 599-604 Citation Subset: IM |
Affiliation:
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Child Development Center, Department of Pediatrics, Rhode Island Hospital, Brown University School of Medicine, Providence, RI, USA. sigpueschel@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcarnitine
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administration & dosage* Adult Alzheimer Disease / drug therapy Attention / drug effects Cognition / drug effects* Down Syndrome / drug therapy* Follow-Up Studies Humans Intelligence Tests Male Nootropic Agents / administration & dosage* Social Behavior Treatment Failure Wechsler Scales |
| Chemical | |
Reg. No./Substance:
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0/Nootropic Agents; 14992-62-2/Acetylcarnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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