Document Detail

The effect of acetazolamide and carbon dioxide on cerebral hemodynamic changes on near-infrared spectroscopy in young rabbits.
MedLine Citation:
PMID:  7503388     Owner:  NLM     Status:  MEDLINE    
The changes of cerebral blood oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), and total hemoglobin (tHb) induced by acetazolamide and CO2 loading on near-infrared spectroscopy (NIRS) were recorded. In anesthetized 2-week-old rabbits, acetazolamide (10 mg/kg i.v.) increased HbO2 and tHb, concomitant with an increase in tissue PCO2, and decreased HbR only at 5 and 10 min. CO2 loading significantly increased HbR and decreased HbO2, and after the termination of CO2 loading, tHb and HbO2 significantly increased and HbR decreased to nearly the baseline value. Thus, NIRS demonstrated cerebral hemodynamic responses as a function of vasomotor reactivity to acetazolamide as well as CO2 loading.
H Kimoto; T Ohno; S Takashima; S Hirano; T Ozaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  17     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1996-01-17     Completed Date:  1996-01-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  IM    
Division of Neonatology, Saitama Children's Medical Center, Iwatsuki-shi, Japan.
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MeSH Terms
Acetazolamide / pharmacology*
Blood Pressure / drug effects
Carbon Dioxide / metabolism,  pharmacology*
Carbonic Anhydrase Inhibitors / pharmacology*
Cerebrovascular Circulation / drug effects*
Heart Rate / drug effects
Hemoglobins / metabolism
Oxyhemoglobins / metabolism
Spectrophotometry, Infrared
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 0/Hemoglobins; 0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 9008-02-0/deoxyhemoglobin

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