Document Detail


The effect of acetazolamide and carbon dioxide on cerebral hemodynamic changes on near-infrared spectroscopy in young rabbits.
MedLine Citation:
PMID:  7503388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The changes of cerebral blood oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), and total hemoglobin (tHb) induced by acetazolamide and CO2 loading on near-infrared spectroscopy (NIRS) were recorded. In anesthetized 2-week-old rabbits, acetazolamide (10 mg/kg i.v.) increased HbO2 and tHb, concomitant with an increase in tissue PCO2, and decreased HbR only at 5 and 10 min. CO2 loading significantly increased HbR and decreased HbO2, and after the termination of CO2 loading, tHb and HbO2 significantly increased and HbR decreased to nearly the baseline value. Thus, NIRS demonstrated cerebral hemodynamic responses as a function of vasomotor reactivity to acetazolamide as well as CO2 loading.
Authors:
H Kimoto; T Ohno; S Takashima; S Hirano; T Ozaki
Related Documents :
9602598 - Relationship between end-tidal and arterial carbon dioxide partial pressure using a cuf...
8297938 - Effects of a continuous infusion of tris(hydroxymethyl)aminomethane on acidosis, oxygen...
719998 - Comparison of cardiac output determined by a carbon dioxide-rebreathing and direct fick...
3745048 - Ventilatory responses to partial cardiopulmonary bypass at rest and exercise in dogs.
7777668 - Cellular adaptations of the myocardium to chronic exercise.
19198198 - Musculoskeletal injuries and minor trauma in space: incidence and injury mechanisms in ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  17     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:    1995 Jul-Aug
Date Detail:
Created Date:  1996-01-17     Completed Date:  1996-01-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  261-3     Citation Subset:  IM    
Affiliation:
Division of Neonatology, Saitama Children's Medical Center, Iwatsuki-shi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetazolamide / pharmacology*
Animals
Blood Pressure / drug effects
Carbon Dioxide / metabolism,  pharmacology*
Carbonic Anhydrase Inhibitors / pharmacology*
Cerebrovascular Circulation / drug effects*
Female
Heart Rate / drug effects
Hemoglobinometry
Hemoglobins / metabolism
Oxyhemoglobins / metabolism
Pregnancy
Rabbits
Spectrophotometry, Infrared
Chemical
Reg. No./Substance:
0/Carbonic Anhydrase Inhibitors; 0/Hemoglobins; 0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 9008-02-0/deoxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intracellular alkalosis during hypoxia in newborn mouse brain in the presence of systemic acidosis: ...
Next Document:  Effects of neonatal hypoxia on brainstem cholinergic neurons-pedunculopontine nucleus and laterodors...