| The effect of Trasylol and vasopressin on experimental pancreatitis. | |
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MedLine Citation:
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PMID: 6154320 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A dog model was established to measure the hemodynamic changes occurring during experimental pancreatitis. The effect of treatment with Trasylol and vasopressin, beginning 60 minutes after induction of pancreatitis was assessed by their effect on the pancreatic hemodynamics. The pancreatic arterial blood flow fell by 72 per cent in the dogs with induced pancreatitis and treated only with saline solution. In contrast, the pancreatic blood flow fell by 58 per cent in the Trasylol group and 80 per cent in the vasopressin group. In addition, vasopressin had a detrimental effect on the cardiac output. Neither treatment altered the changes noted in the systemic blood pressure. Trasylol had a slight beneficial effect on experimental pancreatitis when assessed by its effect on the pancreatic hemodynamics. In contrast, vasopressin had a detrimental effect on the pancreatic hemodynamics. |
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Authors:
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L A Donaldson; W G Schenk |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Surgery, gynecology & obstetrics Volume: 150 ISSN: 0039-6087 ISO Abbreviation: Surg Gynecol Obstet Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-06-27 Completed Date: 1980-06-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101370 Medline TA: Surg Gynecol Obstet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 657-60 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Aprotinin / pharmacology*, therapeutic use Blood Pressure / drug effects Cardiac Output / drug effects Dogs Hemodynamics / drug effects* Pancreas / blood supply Pancreatitis / drug therapy*, physiopathology Regional Blood Flow / drug effects Vasopressins / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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11000-17-2/Vasopressins; 9087-70-1/Aprotinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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