Document Detail

The effect of TPP, theophylline and theobromine on the angiogenic activity of mononuclear leucocytes obtained from diabetic patients with proliferative retinopathy.
MedLine Citation:
PMID:  7518638     Owner:  NLM     Status:  MEDLINE    
Tołpa Peat Preparation (TPP) administered in various doses does not influence the ability of mononuclear cells (MNC) obtained from diabetic patients with proliferative retinopathy to induce neovascularization response in H-LIA test. Methylxanthines (theophylline, theobromine) significantly decrease the angiogenic activity of these cells. The therapeutic value of these drugs in proliferative retinopathy should be evaluated.
P Skopiński; M Zukowska; W Małkowska-Zwierz; D Radomska; D Retelska; D Kecik; M Domosławski; A Sobczyńska; M Pawińska; E Skopińska-Rózewska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta poloniae pharmaceutica     Volume:  50     ISSN:  0001-6837     ISO Abbreviation:  Acta Pol Pharm     Publication Date:  1993  
Date Detail:
Created Date:  1994-08-16     Completed Date:  1994-08-16     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  2985167R     Medline TA:  Acta Pol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  409-11     Citation Subset:  IM    
Laboratory of Electron Microscopy, Institute of Biostructure, School of Medicine, Warsaw, Poland.
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MeSH Terms
Amino Acids / pharmacology*
Carbohydrates / pharmacology*
Diabetic Retinopathy / pathology*
Drug Combinations
Humic Substances / pharmacology*
Leukocytes, Mononuclear / drug effects*,  physiology
Mice, Inbred BALB C
Neovascularization, Pathologic / etiology*
Theobromine / pharmacology*
Theophylline / pharmacology*
Uronic Acids / pharmacology*
Reg. No./Substance:
0/Amino Acids; 0/Carbohydrates; 0/Drug Combinations; 0/Humic Substances; 0/Soil; 0/Tolpa; 0/Uronic Acids; 58-55-9/Theophylline; 83-67-0/Theobromine

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