| The effect of T cell growth factor on the cell cycle of primate T cells. | |
| | |
MedLine Citation:
|
PMID: 6981667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of T cell growth factor (TCGF) on the cell cycle of four T cell lines that differed in their response to TCGF was studied. Activated normal marmoset T cells (OH-1) were totally dependent on the addition of TCGF for long-term proliferation. In the absence of TCGF, the cells were incapable of traversing the cell cycle and became arrested in G1. The addition of TCGF to arrested OH-1 cells stimulated them to enter the S phase after a lag phase of 24 to 33 hr. The TCGF-stimulated cells reached a maximum of cells in the S phase by 12 hr after the initiation of DNA synthesis. TCGF was required for a minimum of 18 hr before cells would enter the S phase. In the absence of TCGF, activated owl monkey (8I) and human (RG) lymphocytes displayed a TCGF-sensitive block; addition of TCGF stimulated these cells to enter the S phase after 12 and 16 hr, respectively. In contrast, an owl monkey tumor-derived T cell line (OMT-1), not dependent on exogenous TCGF for proliferation, was able to progress slowly through the cell cycle without a TCGF-sensitive block. These cells responded to TCGF by showing an initial increase in cells that entered the S phase after a lag of 6 hr and a continuing movement of additional cells into S over the course of the next several hours. |
| | |
Authors:
|
R L Brown; R L Griffith; R H Neubauer; H Rabin |
Related Documents
:
|
12913157 - Constitutive e2f expression in tobacco plants exhibits altered cell cycle control and m... 21262837 - Requirement for ribosomal protein s6 kinase 1 to mediate glycolysis and apoptosis resis... 11264957 - Methods for cell cycle analysis and detection of apoptosis of teleost cells. 20460507 - The limitations of the g1-s checkpoint. 17282957 - Segmenting and counting of wall-pasted cells based on gabor filter. 8490807 - Dynamics and regulation of bulk milk somatic cell counts. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 129 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1982 Nov |
Date Detail:
|
Created Date: 1982-12-03 Completed Date: 1982-12-03 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1849-53 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aotus trivirgatus Cell Cycle Cell Line Cell Transformation, Neoplastic / metabolism Culture Media DNA / biosynthesis Humans Interleukin-2 / pharmacology* Interphase Saguinus T-Lymphocytes / cytology* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
N01-CO-75380/CO/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Culture Media; 0/Interleukin-2; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo and in vitro effect of the Haemophilus influenzae lipopolysaccharide on ciliated respiratory...
Next Document: Induction of IgG production in a human monoclonal B lymphoblastoid cell line by a B cell-specific mo...