Document Detail


The effect of PMSG dose on the incidence of chromosomal anomalies in mouse embryos fertilized in vitro.
MedLine Citation:
PMID:  881666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromosomal analysis of first-cleavage mouse embryos obtained by fertilization of TO eggs with TO spermatozoa in vitro revealed that the incidence of polyploidy was proportional to the dose of PMSG given to the donor females. The dose-response was shown to be linear, with the level of polyploidy rising from 8-0% with a PMSG dose of 1-5 i.u./female to 20-8% with 10-0 i.u./female. A total of 64 polyploid embryos was found among the 452 examined and in all cases the polyploidy was the result of polyspermy or fertilization by diploid spermatozoa.
Authors:
I Maudlin; L R Fraser
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  50     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy*
Animals
Dose-Response Relationship, Drug
Female
Fertilization* / drug effects
Gonadotropins, Equine / administration & dosage,  pharmacology*
Mice
Polyploidy*
Pregnancy
Chemical
Reg. No./Substance:
0/Gonadotropins, Equine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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