| The effect of PHA-activated MN-cell supernatants on polymorphonuclear leucocyte function. | |
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MedLine Citation:
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PMID: 589867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of PHA-activated mononuclear-cell (MN) supernatants on various polymorphonuclear-leucocyte (PMN) functions were assessed. Treatment of PMN with PHA-activated MN-cell supernatants resulted in greater electrophoretic mobility, indicating an increase in the negative surface charge. PMN directional motility was inhibited in the presence of active supernatants but was not affected by a pulse exposure of the PMN to these supernatants. Neither control nor active supernatants were chemotactic for PMN, but treatment of these cells with active supernatants produced an increase in their phagocytic activity, their ability to reduce NBT and in their glucose oxidation through the hexosemonophosphate shunt. Bactericidal capacity of these PMN was unaltered. Specific loss of leucocyte inhibitory factor (LIF) activity from supernatants of PHA-activated MN cells followed their absorption with PMN cells but not with human MN cells or guinea-pig peritoneal exudate cells. Furthermore, acquired inhibition of migration of the absorbing PMN was observed. |
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Authors:
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R Lomnitzer; A Glover; A R Rabson |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 29 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 501-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Bactericidal Activity Chemotaxis, Leukocyte Electrophoresis Glucose / metabolism Humans Leukocytes / immunology Lymphokines* Membrane Potentials Neutrophils / metabolism, physiology* Phagocytosis |
| Chemical | |
Reg. No./Substance:
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0/Lymphokines; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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