Document Detail

The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats.
MedLine Citation:
PMID:  16249925     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The antioxidant potential N-Acetylcysteine (NAC) and its improvement of posttraumatic mitrochondrial dysfunction have been reported. This study investigated the effect of NAC on posttraumatic changes after controlled cortical Impact (CCI) injury. DESIGN AND SETTING: Prospective randomized controlled animal study. METHODS: A moderate left focal cortical contusion was induced using CCI. Either NAC (163 mg/kg bw) or physiological saline was administered intraperitoneally immediately and 2 and 4 h after trauma. Blood gases, temperature, mean arterial blood pressure (MABP), and intracranial pressure (ICP) were monitored. Twenty-four hours after trauma brains were removed and either posttraumatic edema was quantified gravimetrically (n=24], or contusion volume was determined morphometrically using slices staining and computerized image analysis (n=24]. Laser Doppler flowmetry was used to assess pericontusional cortical perfusion before trauma, 30 min and 4 and 24 h after trauma (n=14]. MEASUREMENTS AND RESULTS: Physiological parameters remained within normal limits. ICP measurements and water content in traumatized hemispheres did not differ between the groups. Relative contusion volume of the left hemisphere was slightly but nonsignificantly diminished in NAC-treated animals (4.7+/-0.4% vs. 5.9+/-0.5% in controls). In both groups pericontusional perfusion was significantly reduced at 4 h followed by a state of hyperperfusion at 24 h with no differences between the groups. CONCLUSIONS: Despite previously reported neuroprotective abilities of NAC, no positive effect on posttraumatic perfusion, brain edema formation, or contusion volume after focal brain injury was observed in this study.
Ulrich-Wilhelm Thomale; Martin Griebenow; Stefan-Nikolaus Kroppenstedt; Andreas W Unterberg; John F Stover
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-26
Journal Detail:
Title:  Intensive care medicine     Volume:  32     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-04     Completed Date:  2006-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Department of Neurosurgery, Charité, Virchow Medical Center, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany.
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MeSH Terms
Acetylcysteine / pharmacology*
Brain Edema / prevention & control
Brain Injuries / drug therapy*
Cerebrovascular Circulation / drug effects
Free Radical Scavengers / pharmacology*
Random Allocation
Rats, Sprague-Dawley
Reg. No./Substance:
0/Free Radical Scavengers; 616-91-1/Acetylcysteine

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