| The effect of MK-801 on cortical spreading depression in the penumbral zone following focal ischaemia in the rat. | |
| | |
MedLine Citation:
|
PMID: 1314840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cortical spreading depression (CSD) is a transient depression of neuronal activity that spreads across the cortical surface. In the present studies, we have investigated CSD activity in the penumbral zone following permanent middle cerebral artery (MCA) occlusion in the rat (n = 16/group), using double-barreled Ca(2+)-sensitive microelectrodes. Measurements of CSD activity were made for 3 h in each animal. During this time, a varying number of spontaneous CSDs were seen in the control group (total was 30, with a range of 0-7/rat). These CSDs were of varying duration: "small" (approximately 1 min) and "big" (5-45 min) CSDs. During a CSD, the extracellular [Ca2+] decreased to 0.11 +/- 0.07 mM (mean +/- SD). After 3 h, the extracellular [Ca2+] in the cortex (penumbral zone) was either normal (10/16 rats) or lowered to 0.5 mM (2/16 rats) or to 0.1 mM (4/16 rats). In the caudate nucleus (ischaemic core area), all rats had an extracellular [Ca2+] of approximately 0.1 mM when measured after the 3 h recording period. Neuropathological evaluation of the brains of the animals, which had been allowed to survive for 24 h after MCA occlusion, revealed ischaemic damage in the dorsolateral cortex and caudate nucleus. Administration of the noncompetitive NMDA antagonist, MK-801 (3 mg/kg i.p.), 30 min after MCA occlusion resulted in 24 and 29% reductions in the volume of hemispheric and cortical damage, respectively, which was highly significant (p less than 0.0001); no protection was seen against caudate damage.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
R Gill; P Andiné; L Hillered; L Persson; H Hagberg |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 12 ISSN: 0271-678X ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 1992 May |
Date Detail:
|
Created Date: 1992-05-27 Completed Date: 1992-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 371-9 Citation Subset: IM |
Affiliation:
|
Institute of Neurobiology, University of Göteborg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain Ischemia / drug therapy* Calcium / analysis Cerebral Arterial Diseases / drug therapy* Cerebral Cortex / drug effects*, pathology Dizocilpine Maleate / pharmacology* Male Rats Rats, Inbred Strains Synaptic Transmission / drug effects* Tissue Survival / drug effects |
| Chemical | |
Reg. No./Substance:
|
7440-70-2/Calcium; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of mitosis by okadaic acid: possible involvement of a protein phosphatase 2A in the trans...
Next Document: Acute improvement in histological outcome by MK-801 following focal cerebral ischemia and reperfusio...