Document Detail

The effect of LongoVital on recurrent aphthous stomatitis in a controlled clinical trial.
MedLine Citation:
PMID:  15921331     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to evaluate the effect of daily intake of LongoVital (LV) (herbal vitamin tablets) in the prevention of RAS. MATERIALS AND METHODS: A group of 78 consecutively referred patients was enrolled to a three-months pretreatment period. Fifty subjects were then randomly allocated to an LV-group (n = 25) or a placebo group (N = 25). A double blind, stratified-randomised clinical case-control study was performed during six months. Number and size of the ulcers were registered by the patients using a standardized chart. The degree of discomfort was recorded on a 100 mm horizontal visual analogue scale (VAS-scale). RESULTS: The three-months pretreatment period revealed that the most dominant symptoms were pain (78%) followed by burning sensation (18%). No significant differences between the two groups were found during this period when a comparison was made at the end of the study. After the intervention period the number of aphthous ulcers/month decreased significantly in the LV-group (p = 0.02). The number of days in pain/month were also reduced (p < 0.001). If a 50% reduction of number of aphthous ulcers and days in pain were considered as clinically relevant, no statistical significant differences were found between the groups. CONCLUSION: Thus, no strong evidence was found that justified a recommendation of LV as a general drug for treatment of RAS.
John Bratel; Magnus Hakeberg; Mats Jontell
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral health & preventive dentistry     Volume:  3     ISSN:  1602-1622     ISO Abbreviation:  Oral Health Prev Dent     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-30     Completed Date:  2005-06-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101167768     Medline TA:  Oral Health Prev Dent     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  D; IM    
Clinic of Oral medicine, Odontologen, Public Dental Service, Göteborg, Sweden.
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MeSH Terms
Double-Blind Method
Drug Combinations
Middle Aged
Plant Preparations / therapeutic use*
Plant Structures
Plants, Medicinal
Recurrence / prevention & control
Statistics, Nonparametric
Stomatitis, Aphthous / prevention & control*
Vitamins / therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 0/Plant Preparations; 0/Tablets; 0/Vitamins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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