Document Detail


The effect of LH on the fertilizability and developmental capacity of rat oocytes matured in vitro.
MedLine Citation:
PMID:  439077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of adding LH (10 microgram NIH-LH-B8/ml) to the medium in which oocytes were undergoing maturation in vitro was studied. The fertilizability of the oocytes was evaluated in the sterile oviduct of a unilaterally ovariectomized, mated recipient. Freshly ovulated oocytes, used as a control of the method, were fertilized at a rate of 72%. Only 14% of oocytes matured in culture (without LH) were penetrated by spermatozoa, and 11% were fertilized normally. Addition of LH to the medium increased these proportions to 43 and 33% respectively. Oocytes matured in the presence of LH were able to develop into apparently normal rats. It is concluded that, although oocytes can mature in vitro spontaneously, and that these matured oocytes can be fertilized, addition of LH increases the numbers 3-fold. LH therefore has a direct maturation-promoting action on the rat oocyte-cumulus complex in vitro.
Authors:
R Shalgi; N Dekel; P F Kraicer
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  55     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-07-28     Completed Date:  1979-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fertilization
Luteinizing Hormone / pharmacology*
Oocytes / drug effects,  growth & development*,  transplantation
Ovum / growth & development*
Rats
Chemical
Reg. No./Substance:
9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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