Document Detail

The effect of L-arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction.
MedLine Citation:
PMID:  20865676     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To evaluate the effect of the amino acids L-arginine and citrulline on endothelial function in patients in stable diastolic and right heart failure using photoplethysmography.
METHODS: Thirty patients from the Heart Failure Clinic of the Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" underwent photoplethysmography using the hyperemia technique. Index finger flow was assessed at baseline and after ischemia every 30 s by maximum amplitude time (MAT), total time of the curve (TT) and the index of the two (MAT/TT < 30 = normal) before and after the administration of L-arginine (8 g/day in two doses, n = 15) or citrulline (3 g/day in one dose, n = 15) for 60 days in addition to optimal pharmacological treatment.
RESULTS: There were no statistically significant differences between the two groups at baseline. After the intervention, the MAT/TT index of all patients normalized in each evaluation period with statistically significant differences. Basal L-arginine group = 38.75 ± 11.52, final 23.32 ± 6.08, p = 0.007 and basal citrulline group = 41.4 ± 13.47, final 23.65 ± 6.74, p = 0.007 at 60-90 s. Post-ischemia: basal L-arginine 36.60 ± 11.51, final 18.81 ± 15.13, p = 0.004 and basal citrulline = 49.51 ± 15.17, final 27.13 ± 7.87, p = 0.003.
CONCLUSIONS: The administration of L-arginine and citrulline has a beneficial effect on endothelial function as shown by the normalized MAT/TT index. It probably improves systemic and pulmonary hemodynamics, which could help in the treatment of diastolic heart failure.
Arturo Orea-Tejeda; Juan José Orozco-Gutiérrez; Lilia Castillo-Martínez; Candace Keirns-Davies; Patricia Montano-Hernández; Oscar Vázquez-Díaz; Adrián Valdespino-Trejo; Oscar Infante; Raúl Martínez-Memije
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  464-70     Citation Subset:  IM    
Heart Failure Clinic, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.
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MeSH Terms
Arginine / administration & dosage*
Citrulline / administration & dosage*
Endothelium, Vascular / drug effects*,  physiology
Fingers / blood supply
Heart Failure / drug therapy*,  physiopathology,  ultrasonography
Heart Failure, Diastolic / drug therapy*,  physiopathology,  ultrasonography
Middle Aged
Stroke Volume / physiology*
Vasodilation / drug effects,  physiology
Reg. No./Substance:
372-75-8/Citrulline; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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