| The effect of L-arginine and citrulline on endothelial function in patients in heart failure with preserved ejection fraction. | |
| | |
MedLine Citation:
|
PMID: 20865676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To evaluate the effect of the amino acids L-arginine and citrulline on endothelial function in patients in stable diastolic and right heart failure using photoplethysmography. METHODS: Thirty patients from the Heart Failure Clinic of the Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" underwent photoplethysmography using the hyperemia technique. Index finger flow was assessed at baseline and after ischemia every 30 s by maximum amplitude time (MAT), total time of the curve (TT) and the index of the two (MAT/TT < 30 = normal) before and after the administration of L-arginine (8 g/day in two doses, n = 15) or citrulline (3 g/day in one dose, n = 15) for 60 days in addition to optimal pharmacological treatment. RESULTS: There were no statistically significant differences between the two groups at baseline. After the intervention, the MAT/TT index of all patients normalized in each evaluation period with statistically significant differences. Basal L-arginine group = 38.75 ± 11.52, final 23.32 ± 6.08, p = 0.007 and basal citrulline group = 41.4 ± 13.47, final 23.65 ± 6.74, p = 0.007 at 60-90 s. Post-ischemia: basal L-arginine 36.60 ± 11.51, final 18.81 ± 15.13, p = 0.004 and basal citrulline = 49.51 ± 15.17, final 27.13 ± 7.87, p = 0.003. CONCLUSIONS: The administration of L-arginine and citrulline has a beneficial effect on endothelial function as shown by the normalized MAT/TT index. It probably improves systemic and pulmonary hemodynamics, which could help in the treatment of diastolic heart failure. |
| | |
Authors:
|
Arturo Orea-Tejeda; Juan José Orozco-Gutiérrez; Lilia Castillo-Martínez; Candace Keirns-Davies; Patricia Montano-Hernández; Oscar Vázquez-Díaz; Adrián Valdespino-Trejo; Oscar Infante; Raúl Martínez-Memije |
Related Documents
:
|
11077226 - Experience with beta-blocker therapy in patients with advanced heart failure evaluated ... 11196456 - Risk factors associated with persistent postoperative hypertension in cushing's syndrome. 15921806 - Exchange of beta-blockers in heart failure patients. experiences from the poststudy pha... 2441166 - Effects of transdermal clonidine in young and elderly patients with mild hypertension: ... 9774126 - Prospective evaluation of an anemia treatment algorithm in hemodialysis patients. 12187336 - Importance of right subcostal incisions in patients undergoing tram flap breast reconst... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Cardiology journal Volume: 17 ISSN: 1897-5593 ISO Abbreviation: Cardiol J Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-09-24 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101392712 Medline TA: Cardiol J Country: Poland |
Other Details:
|
Languages: eng Pagination: 464-70 Citation Subset: IM |
Affiliation:
|
Heart Failure Clinic, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Arginine / administration & dosage* Citrulline / administration & dosage* Echocardiography Endothelium, Vascular / drug effects*, physiology Female Fingers / blood supply Heart Failure / drug therapy*, physiopathology, ultrasonography Heart Failure, Diastolic / drug therapy*, physiopathology, ultrasonography Humans Male Middle Aged Photoplethysmography Stroke Volume / physiology* Vasodilation / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
|
372-75-8/Citrulline; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fa...
Next Document: Does atrial fibrillation affect plasma endothelin level?