Document Detail


The effect of the K+ agonist nicorandil on peripheral vascular resistance.
MedLine Citation:
PMID:  16055211     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The vasoactive effect of nicorandil on coronary arteries is well known. Nicorandil exerts its vasodilatory effect through a dual mechanism of action: involving on the one hand cyclic guanosine monophosphate (c GMP) as a nitrovasodilatator, and on the other hand, acting as a potassium channel opener. OBJECTIVE: To address the question if nicorandil works in peripheral arteries, its effect on peripheral vascular resistance was evaluated in isolated perfused guinea pig hind limbs. METHODS: A catheter was inserted via the distal aorta and common iliac artery. Perfusion pressure was monitored under constant perfusion with Tyrode's solution, therefore changes in perfusion pressure represent changes in vascular resistance. After stabilization precontraction of the peripheral vascular bed was achieved with noradrenaline 3 microM and nicorandil was added in concentrations of 1, 10 and 100 microM. The effect of nicorandil (1, 10 and 100 microM) was tested in the presence of L-NAME and glybenclamide. RESULTS: A significant reduction of vascular peripheral resistance was already achieved at a concentration of 1 microM nicorandil (30.3+/-6.1%, mean S.E.M., p < 0.001). At a concentration of 100 microM nicorandil the reduction of peripheral vascular resistance was 94.4+/-16.4%. Peripheral vascular resistance was less but nearly comparable reduced by nicorandil (100 microM) if the endothelial NO effect was inhibited by L-NAME (58.6+/-18.6%) or if the ATP-dependent potassium channels were blocked by glybenclamide (56.4+/-14.6%). CONCLUSIONS: In peripheral arteries the nitrovasodilator effect of nicorandil is nearly comparable to the potassium agonistic effect, and the concentration, which is necessary to reduce peripheral vascular resistance significantly, is comparable with dosages necessary for reduction of coronary resistance.
Authors:
Marianne Brodmann; Ulrike Lischnig; Andreas Lueger; Gerhard Stark; Ernst Pilger
Publication Detail:
Type:  Journal Article     Date:  2005-08-02
Journal Detail:
Title:  International journal of cardiology     Volume:  111     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Affiliation:
Working group of Clinical Pharmacotherapy, Department of Internal Medicine, Medizinische Universität Graz, Austria. marianne.brodmann@meduni-graz.at
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Guinea Pigs
Male
Nicorandil / pharmacology*
Potassium Channels / agonists*
Vascular Resistance / drug effects*
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Potassium Channels; 0/Vasodilator Agents; 65141-46-0/Nicorandil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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