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The effect of IL-1 receptor antagonist on orthodontic tooth movement in mice.
MedLine Citation:
PMID:  22024406     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Orthodontic tooth movement (OTM) is achieved by alveolar bone remodelling induced by mechanical loading. Whilst interleukin-1 (IL-1) is directly involved in OTM, the role of interleukin-1 receptor antagonist (IL-1Ra), a naturally occurring IL-1 antagonist, is not completely defined. Therefore, the aim of this study was to investigate the effects of IL-1Ra on OTM. METHODS: An orthodontic appliance was placed in C57BL6 mice treated with vehicle or IL-1Ra (10mg/kg/day). OTM and TRAP-positive osteoclasts were evaluated after 12 days of mechanical loading and the levels of cytokines on periodontal tissues were analysed by ELISA after 12 and 72h. RESULTS: Mice treated with IL-1Ra showed diminished OTM and decreased numbers of TRAP-positive osteoclasts. In line with this, lower levels of IL-1β and TNF-α, and higher levels of IL-10, were observed on periodontal tissues of IL-1Ra-treated mice in relation to the vehicle-treated group. CONCLUSION: The present study suggests that IL-1Ra downregulates OTM, probably by its anti-inflammatory actions.
Authors:
Juliana Tito Salla; Silvana Rodrigues de Albuquerque Taddei; Celso Martins Queiroz-Junior; Ildeu Andrade Junior; Mauro Martins Teixeira; Tarcília Aparecida Silva
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-22
Journal Detail:
Title:  Archives of oral biology     Volume:  -     ISSN:  1879-1506     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Oral Surgery and Pathology, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
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