| The effect of HAART and calendar period on Kaposi's sarcoma and non-Hodgkin lymphoma: results of a match between an AIDS and cancer registry. | |
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MedLine Citation:
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PMID: 21139489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the impact of HAART use on AIDS-defining Kaposi's sarcoma and non-Hodgkin lymphoma (NHL) among adults with AIDS. DESIGN: Registry linkage study. METHODS: Adults diagnosed with AIDS from 1990 to 2000 in the San Francisco AIDS case registry were matched with cancer cases diagnosed from 1985 to 2002 in the California Cancer Registry. Multivariate Cox proportional hazard models were used to evaluate the risk and survival of AIDS-related Kaposi's sarcoma, systemic NHL, and primary central nervous system (CNS) lymphoma. RESULTS: Of the 14 183 adults with AIDS, 3028 were diagnosed with Kaposi's sarcoma, 776 with systemic NHL, and 254 with CNS NHL. After adjustment for potential confounders, more recent calendar period and use of HAART were significantly associated with a decreased risk of Kaposi's sarcoma, whereas HAART use but not calendar period was significantly associated with systemic and CNS NHL. In adjusted analysis of Kaposi's sarcoma survival time, there was strong evidence of a reduced risk of death associated with HAART use and more recent calendar period. In contrast, in adjusted analyses of systemic NHL survival time, HAART use was not associated with improved survival time; however, calendar period was associated with longer survival. In adjusted analysis of CNS NHL survival time, only cancer treatment was associated with a longer survival time. CONCLUSION: After controlling for calendar period and other confounders, use of HAART decreased the risk of Kaposi's sarcoma, systemic NHL, and CNS NHL. Use of HAART also increased Kaposi's sarcoma survival time but not NHL survival time. |
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Authors:
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Sharon Pipkin; Susan Scheer; Ijeoma Okeigwe; Sandra Schwarcz; David H Harris; Nancy A Hessol |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: AIDS (London, England) Volume: 25 ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-06-06 Revised Date: 2012-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 463-71 Citation Subset: IM; X |
Affiliation:
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San Francisco Department of Public Health, AIDS Office, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications,
drug therapy*,
epidemiology Adolescent Adult Aged Aged, 80 and over Antiretroviral Therapy, Highly Active Female Humans Lymphoma, AIDS-Related / drug therapy*, epidemiology Male Middle Aged Registries Sarcoma, Kaposi / drug therapy*, epidemiology Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R03 AI055270-01/AI/NIAID NIH HHS; R03 AI055270-02/AI/NIAID NIH HHS; R03-AI055270/AI/NIAID NIH HHS |
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