| The effect of D-(+)-glucosamine on levels of free N-acetylneuraminic acid and UDP-N-acetylhexosamines in infantile sialic acid storage disease (ISSD) fibroblasts. | |
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MedLine Citation:
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PMID: 3106716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An impairment in the regulation of N-acetylneuraminic acid (NANA) biosynthesis might potentially contribute to accumulation of free NANA in fibroblasts of patients with sialic acid storage disease (ISSD). By the use of a glucosamine loading test an increase in uridine-diphosphate-N-acetyl-hexosamines (UDP-HexNAc) but not in free NANA was found. NANA biosynthesis therefore appears to be under normal regulatory control in ISSD. |
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Authors:
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E Paschke; G Höfler; A Roscher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of inherited metabolic disease Volume: 10 ISSN: 0141-8955 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 1987 |
Date Detail:
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Created Date: 1987-06-05 Completed Date: 1987-06-05 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 48-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fibroblasts
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analysis Glucosamine / pharmacology* Humans Infant Male Metabolism, Inborn Errors / metabolism* N-Acetylneuraminic Acid Sialic Acids / analysis, metabolism* Uridine Diphosphate N-Acetylglucosamine / analysis Uridine Diphosphate Sugars / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Sialic Acids; 0/Uridine Diphosphate Sugars; 131-48-6/N-Acetylneuraminic Acid; 3416-24-8/Glucosamine; 528-04-1/Uridine Diphosphate N-Acetylglucosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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