| The effect of Chlamydophila pneumoniae Major Outer Membrane Protein (MOMP) on macrophage and T cell-mediated immune responses. | |
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MedLine Citation:
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PMID: 20637522 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Major Outer Membrane Protein (MOMP) belongs to the membrane complex of cysteine-rich proteins of Chlamydophila pneumoniae. Although MOMP can elicit strong immune responses it fails to confer long-term protection against infection in animal models. This effect has been attributed, at least in part, to an inadequate induction of protective Th1-mediated immune responses. In an effort to understand the cellular mechanisms associated to the immunomodulatory properties of MOMP we studied the effect of this protein on mouse macrophages and naïve T-lymphocytes. We found that incubation of mouse macrophages with recombinant MOMP (rMOMP) results in an increased secretion of MMP-9 and a down-regulation of MHC class II, CD86 and CD40. This was accompanied by an increase in IL-10 and IFNγ but not in IL-12 secretion. rMOMP induced a down-regulation of the expression of CD69 and CD154 markers by activated CD4(+) T cells, and enhanced the secretion of IL-2 and IL-10 by these cells. Conversely, rMOMP-treated macrophages up-regulated the expression of CD69 but not CD154, inhibited the synthesis of IL-10 and up-regulated the production of IFNγ by activated CD8(+) T cells. Immunization of mice with MOMP induced the synthesis only of MOMP-specific IgG1 but no differences in cytokine profile were observed compared to controls. Our results provide new evidence on the role of MOMP in modulating T cell-mediated immune responses. |
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Authors:
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Alexandra Bermudez-Fajardo; Anne-Katrien Stark; Rehab El-Kadri; Manuel L Penichet; Katharina Hölzle; Max M Wittenbrink; Ludwig Hölzle; Ernesto Oviedo-Orta |
Publication Detail:
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Type: Journal Article Date: 2010-06-22 |
Journal Detail:
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Title: Immunobiology Volume: 216 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 152-63 Citation Subset: IM |
Copyright Information:
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Crown Copyright © 2010. Published by Elsevier GmbH. All rights reserved. |
Affiliation:
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University of Surrey, Faculty of Health and Medical Sciences, Guildford, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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