| The effect of CC14 on uterine ornithine decarboxylase (ODC) in the rat. Inhibition by CC14 of the induction of ODC by E2 and o,p'DDT. | |
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MedLine Citation:
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PMID: 959654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The oral administration of carbon tetrachloride (CC14) to ovariectomized rats markedly inhibited the elevation of uterine decarboxylase (ODC) by estradiol-17beta (E2) and by 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2,2-trichloroethane (o,p'DDT). The inhibition of ODC induction by CC14 does not appear to be mediated by the formation of an inhibitor of ODC activity. CC14 treatment caused no observable alteration in the uterine cytosolic E2 receptor. Namely, there was no alteration by CC14 in the number of E2 binding sites, in the affinity of the receptor for E2 or in the sedimentation constant of the 8S receptor. Furthermore, the possibility that CC14 inhibition of ODC induction is a resultant of an initial stimulation of this uterine enzyme by CC14 was excluded. The potential inhibitory effect of CC14 by direct of indirect route on uterine protein synthesis is discussed. |
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Authors:
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W H Bulger; D Kupfer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 14 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1976-11-01 Completed Date: 1976-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 497-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Tetrachloride / pharmacology* Carboxy-Lyases / metabolism* Centrifugation, Density Gradient Cytochrome P-450 Enzyme System / metabolism DDT / pharmacology* Depression, Chemical Dextrans / diagnostic use Enzyme Activation / drug effects Estradiol / pharmacology* Female Hexobarbital / metabolism Microsomes, Liver / enzymology Ornithine Decarboxylase / metabolism* Rats Uterus / enzymology* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 50-29-3/DDT; 56-23-5/Carbon Tetrachloride; 56-29-1/Hexobarbital; 9004-54-0/Dextrans; 9035-51-2/Cytochrome P-450 Enzyme System; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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