Document Detail

The effect of BW 540C, a novel anti-inflammatory agent, on ultraviolet-induced physical and histological changes in guinea-pig skin.
MedLine Citation:
PMID:  4015980     Owner:  NLM     Status:  MEDLINE    
We have examined the effects of various topical formulations of BW 540C, a novel dual inhibitor of the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism, utilizing the model of ultraviolet irradiation of guinea-pig ears. During a series of studies, BW 540C preparations were compared with a range of corticosteroids, a cyclo-oxygenase inhibitor and a placebo using both subjective and objective measurements. Results showed BW 540C base to be the best overall agent for treating the pathological changes seen in this model.
B Dawson; R L Follenfant; G A Higgs; C Schneider; J R Gibson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  113 Suppl 28     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-05     Completed Date:  1985-09-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents / administration & dosage,  therapeutic use*
Dermatitis / drug therapy*,  etiology
Disease Models, Animal
Drug Administration Schedule
Guinea Pigs
Pyrazoles / administration & dosage,  therapeutic use*
Skin / drug effects,  radiation effects
Ultraviolet Rays
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Pyrazoles; 83908-32-1/BW 540C

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