Document Detail

The effect of B-HT 920, a dopamine D2 agonist, on bar-press feeding in the monkey.
MedLine Citation:
PMID:  7914026     Owner:  NLM     Status:  MEDLINE    
Although the dopamine (DA) system has been shown to regulate food intake, the function of the DA receptor subtypes on behavior still remains to be elucidated. In the present study, we examined the effect of B-HT 920, a selective agonist of DA D2 receptors that preferentially affect presynaptic autoreceptors, on both food consumption and execution of a high fixed-ratio bar-press task for food reward in monkeys. Two kinds of bar-press task were used: 1) a cue-triggered bar-press task during the first 40 trials, and 2) a self-paced bar-press task in which the monkeys freely performed bar-press trials until they were satiated. A SC injection of B-HT 920 (25 micrograms/kg) increased food consumption in the home cage. The same facilitatory effect on food consumption was also observed in the operant task condition. During the cue-triggered bar-press task, however, both the latency of the bar-press responses to a cue light and the time required to complete the bar-press trials were prolonged after the injection of B-HT 920. The results suggest that the activation of D2 autoreceptors suppresses the operant food acquisition behavior and increases food consumption through an inhibition of the satiety mechanism rather than an activation of any hunger-related drive.
S Aou; M Mizuno; T Hori; K Yamada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  55     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-30     Completed Date:  1994-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1125-30     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Appetitive Behavior / drug effects*
Azepines / pharmacology*
Brain / drug effects
Dopamine Agents / pharmacology*
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Macaca mulatta
Receptors, Dopamine D2 / drug effects*
Reinforcement Schedule
Social Environment
Reg. No./Substance:
0/Azepines; 0/Dopamine Agents; 0/Receptors, Dopamine D2; 36085-73-1/talipexole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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