| The effect of Allium sativum on ischemic preconditioning and ischemia reperfusion induced cardiac injury. | |
| | |
MedLine Citation:
|
PMID: 21279182 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
In the present study, the effect of garlic (Allium sativum) extract on ischemic preconditioning and ischemia-reperfusion induced cardiac injury has been studied. Hearts from adult albino rats of Wistar strain were isolated and immediately mounted on Langendorff's apparatus for retrograde perfusion. After 15 minutes of stabilization, the hearts were subjected to four episodes of 5 min ischemia, interspersed with 5 min reperfusion (to complete the protocol of ischemic preconditioning), 30 min global ischemia, followed by 120 min of reperfusion. In the control and treated groups, respective interventions were given instead of ischemic preconditioning. The magnitude of cardiac injury was quantified by measuring Lactate Dehydrogenase and creatine kinase concentration in the coronary effluent and myocardial infarct size by macroscopic volume method. Our study demonstrates that garlic extract exaggerates the cardio protection offered by ischemic preconditioning and per se treatment with garlic extract also protects the myocardium against ischemia reperfusion induced cardiac injury. |
| | |
Authors:
|
Rajbir Bhatti; Kushlinder Singh; M P S Ishar; Jatinder Singh |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Indian journal of pharmacology Volume: 40 ISSN: 0253-7613 ISO Abbreviation: Indian J Pharmacol Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2011-01-31 Completed Date: 2011-07-14 Revised Date: 2013-05-29 |
Medline Journal Info:
|
Nlm Unique ID: 7902477 Medline TA: Indian J Pharmacol Country: India |
Other Details:
|
Languages: eng Pagination: 261-5 Citation Subset: - |
Affiliation:
|
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antidiabetic activity of flower buds of Michelia champaca Linn.
Next Document: Antioxidant potential of the methanol-methylene chloride extract of Terminalia glaucescens leaves on...