Document Detail

The effect of 7.2% hypertonic saline solution with 6% dextran 70 on cardiac contractility as observed by an echocardiography in normovolemic and anesthetized dogs.
MedLine Citation:
PMID:  18250578     Owner:  NLM     Status:  MEDLINE    
We studied the effect of a small volume of 7.2% hypertonic saline solution (HSS) or HSS with 6% dextran 70 (HSD) on hemodynamic status, especially on cardiac contractility, in anesthetized dogs using the left ventricular end-systolic volume index (ESVI) and ejection fraction (EF), which can be obtained in noninvasive echocardiography. In the present study, the mean values of ESVI were unaffected by HSS and HSD infusion, whereas the left ventricular end-diastolic volume index (EDVI) was markedly and significant increased. As a result of the changes in EDVI but not in ESVI, EF increased transiently and significantly in the HSS and HSD group, whereas no such significant change was observed in the dogs that received isotonic saline solution. In addition, as a result of the increases in cardiac index but not arterial pressure, system vascular resistances (SVR) decreased transiently and significantly in the HSS and HSD groups, whereas no such significant change was observed in the ISS group. Therefore, the positive inotropic effects of HSS and HSD may be attributable to the increase in left ventricular preload and decreases in SVR rather than direct changes in myocardial contractility.
Kazuyuki Suzuki; Masato Otake; Yuuto Saida; Hiroshi Koie; Ryuji Asano
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  70     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
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MeSH Terms
Dextrans / pharmacology*
Echocardiography, Transesophageal / veterinary*
Myocardial Contraction / drug effects*
Saline Solution, Hypertonic / pharmacology*
Time Factors
Reg. No./Substance:
0/Saline Solution, Hypertonic; 9004-54-0/Dextrans

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